The adaptive transition of glioblastoma stem cells and its implications on treatments

Z Wang, H Zhang, S Xu, Z Liu, Q Cheng - Signal transduction and …, 2021 - nature.com
Glioblastoma is the most malignant tumor occurring in the human central nervous system
with overall median survival time< 14.6 months. Current treatments such as chemotherapy …

Dysregulation of inflammasome activation in glioma

JM Sim, JM Park, JS Moon, J Lim - Cell Communication and Signaling, 2023 - Springer
Gliomas are the most common brain tumors characterized by complicated heterogeneity.
The genetic, molecular, and histological pathology of gliomas is characterized by high neuro …

Molecular mechanisms and current treatment options for cancer cachexia

SS Ahmad, K Ahmad, S Shaikh, HJ You, EY Lee, S Ali… - Cancers, 2022 - mdpi.com
Simple Summary The primary characteristics of cancer cachexia are weakness, weight loss,
atrophy, fat reduction, and systemic inflammation. Cachexia is strongly associated with …

Mdact: A new principle of adjunctive cancer treatment using combinations of multiple repurposed drugs, with an example regimen

RE Kast, A Alfieri, HI Assi, TC Burns, AM Elyamany… - Cancers, 2022 - mdpi.com
Simple Summary We present eight core attributes of cancer growth that we must address for
a more effective treatment than we currently have. To do this we outline why a regimen …

Black Phosphorus as a Targeting PPAR‐γ Agonist to Reverse Chemoresistance in Patient‐derived Organoids, Mice, and Pancreatic Tumor Cells

S Jiang, W Liu, D Shi, H Cheng, T Deng… - Advanced …, 2023 - Wiley Online Library
Black phosphorus (BP) exhibits significant potential for clinical applications. However,
further research is necessary to uncover the unknown biological functions of BP and …

Identification of Cytochrome P450 2E1 as a Novel Target in Glioma and Development of Its Inhibitor as an Anti‐Tumor Agent

G Hu, Y Fang, H Xu, G Wang, R Yang, F Gao… - Advanced …, 2023 - Wiley Online Library
Glioblastoma (GBM) is a devastating inflammation‐related cancer for which novel
therapeutic targets are urgently required. Previous studies of the authors indicate …

Hypoxia and its effect on the cellular system

D Rahane, T Dhingra, G Chalavady… - Cell Biochemistry …, 2024 - Wiley Online Library
Eukaryotic cells utilize oxygen for different functions of cell organelles owing to cellular
survival. A balanced oxygen homeostasis is an essential requirement to maintain the …

A New Vista of Aldehyde Dehydrogenase 1A3 (ALDH1A3): New Specific Inhibitors and Activity-Based Probes Targeting ALDH1A3 Dependent Pathways in …

L Magrassi, G Pinton, S Luzzi, S Comincini… - Cancers, 2024 - mdpi.com
Simple Summary Aldehyde dehydrogenases of the subfamily 1A (ALDH1A) are enzymes
involved in the synthesis of retinoic acid, which is necessary for the normal development and …

Humanin activates integrin αV–TGFβ axis and leads to glioblastoma progression

CP Ha, TNM Hua, VTA Vo, J Om, S Han, SK Cha… - Cell Death & …, 2024 - nature.com
The role of mitochondria peptides in the spreading of glioblastoma remains poorly
understood. In this study, we investigated the mechanism underlying intracranial …

Cell biology meets cell metabolism: energy production is similar in stem cells and in cancer stem cells in brain and bone marrow

CJF van Noorden, B Breznik, M Novak… - … of Histochemistry & …, 2022 - journals.sagepub.com
Energy production by means of ATP synthesis in cancer cells has been investigated
frequently as a potential therapeutic target in this century. Both (an) aerobic glycolysis and …