Monoclonal antibodies (mAbs) are a crucial asset for human health and modern medicine,
however, the repeated administration of mAbs can be highly immunogenic. Drug …

Traditionally, vaccines have been developed by cultivating infectious agents and isolating
the inactivated whole pathogen or some of its purified components. 20 years ago, reverse …

Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have
shown high efficacy, but immunocompromised participants were excluded from controlled …

We conducted a serological study to define correlates of immunity against SARS-CoV-2.
Compared to those with mild coronavirus disease 2019 (COVID-19) cases, individuals with …

The molecular composition and binding epitopes of the immunoglobulin G (IgG) antibodies
that circulate in blood plasma after severe acute respiratory syndrome coronavirus 2 (SARS …

High-throughput immune repertoire sequencing has emerged as a critical step in the
understanding of adaptive responses following infection or vaccination or in autoimmunity …

Studies of the dynamics of the antibody-mediated immune response have been hampered
by the absence of quantitative, high-throughput systems to analyze individual antibody …

We describe the molecular-level composition of polyclonal immunoglobulin G (IgG) anti-
spike antibodies from ancestral severe acute respiratory syndrome coronavirus 2 (SARS …

The adaptive immune system recognizes antigens via an immense array of antigen-binding
antibodies and T-cell receptors, the immune repertoire. The interrogation of immune …

Molecular understanding of serological immunity to influenza has been confounded by the
complexity of the polyclonal antibody response in humans. Here we used high-resolution …