Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …

Protein S-palmitoylation refers to a post-translational modification (PTM) wherein palmitic
acid, a 16-carbon long saturated fatty acid gets covalently attached to Cys sidechain of a …

Autophagy is a highly conserved process from yeast to mammals in which intracellular
materials are engulfed by a double-membrane organelle called autophagosome and …

Protein cysteine palmitoylation, or S‐palmitoylation, has been known for about 40 years, and
thousands of proteins in humans are known to be modified. Because of the large number of …

Posttranslational modifications increase the complexity and functional diversity of proteins in
response to complex external stimuli and internal changes. Among these, protein lipidations …

Palmitoyltransferase (PAT) catalyses protein S-palmitoylation which adds 16-carbon
palmitate to specific cysteines and contributes to various biological functions. We previously …

The outermost barrier layer of the skin is the stratum corneum (SC), which consists of
corneocytes embedded in a lipid matrix. Biosynthesis of barrier lipids occurs de novo in the …

Desmosomes are prominent adhesive junctions present between many epithelial cells as
well as cardiomyocytes. The mechanisms controlling desmosome assembly and remodeling …

zDHHC S-acyltransferases are enzymes catalyzing protein S-acylation, a common post-
translational modification on proteins frequently affecting their membrane targeting and …

The ZDHHC13/ZDHHC17 subfamily belongs to the zinc finger DHHC-domain containing
(ZDHHC) family, including ZDHHC13 and ZDHHC17. Recent studies have shown that the …