Molecular changes in malignant tissue can lead to an increase in the expression levels of
various proteins or receptors that can be used to target the disease. In oncology, diagnostic …

Radiometals possess an exceptional breadth of decay properties and have been applied to
medicine with great success for several decades. The majority of current clinical use …

Background: Recent reports of the remarkable therapeutic efficacy of 225Ac-labeled PSMA-
617 for therapy of metastatic castration-resistant prostate cancer have underlined the clinical …

This review outlines the accomplishments and potential developments of targeted alpha (α)
particle therapy (TAT). It discusses the therapeutic advantages of the short and highly …

Among all existing radionuclides, only a few are of interest for therapeutic applications and
more specifically for targeted alpha therapy (TAT). From this selection, actinium-225 …

The α-emitting radionuclide actinium-225 possesses nuclear properties that are highly
promising for use in targeted α therapy (TAT), a therapeutic strategy that employs α particle …

Recent Food and Drug Administration (FDA) approval of diagnostic and therapeutic
radiopharmaceuticals and concurrent miniaturization of particle accelerators leading to …

In the periodical system, the lanthanides (the 15 elements in the periodic table between
barium and hafnium) are unique in the sense that their trivalent cations have their valence …

Conspectus Nuclear medicine leverages radioisotopes of a wide range of elements, a
significant portion of which are metals, for the diagnosis and treatment of disease. To …

The validation of prostate specific membrane antigen (PSMA) as a molecular target in
metastatic castration-resistant prostate cancer has stimulated the development of multiple …