NADPH oxidases of the Nox family are important enzymatic sources of reactive oxygen
species (ROS). Numerous homologue-specific mechanisms control the activity of this …

Chronic overnutrition creates chronic hyperglycemia that can gradually induce insulin
resistance and insulin secretion impairment. These disorders, if not intervened, will …

Convincing concepts of redox control of gene transcription have been worked out for
prokaryotes and lower eukaryotes, whereas the knowledge on complex mammalian systems …

Nicotinamide adenine dinucleotide phosphate (NAPDH) oxidase (NOX) is an enzyme
complex with the sole function of producing superoxide anion and reactive oxygen species …

Reactive oxygen species (ROS) are generated within activated platelets and play an
important role in regulating platelet responses to collagen and collagen-mediated thrombus …

Macrophage apoptosis in advanced atheromata, a key process in plaque necrosis, involves
the combination of ER stress with other proapoptotic stimuli. We show here that oxidized …

It is now widely accepted, given the current weight of experimental evidence, that reactive
oxygen species (ROS) contribute to cell and tissue dysfunction and damage caused by …

Phagocytes such as neutrophils play a vital role in host defense against microbial
pathogens. The anti-microbial function of neutrophils is based on the production of …

Increased oxidative stress plays an important role in the pathophysiology of cardiovascular
diseases such as hypertension, atherosclerosis, diabetes, cardiac hypertrophy, heart failure …

Neuronal NMDA receptor (NMDAR) activation leads to the formation of superoxide, which
normally acts in cell signaling. With extensive NMDAR activation, the resulting superoxide …