Chikungunya virus (CHIKV), a reemerging arbovirus, causes a crippling musculoskeletal
inflammatory disease in humans characterized by fever, polyarthralgia, myalgia, rash, and …

Arbidol (ARB) is a Russian-made small indole-derivative molecule, licensed in Russia and
China for prophylaxis and treatment of influenza and other respiratory viral infections. It also …

The members of the genus Alphavirus are positive-sense RNA viruses, which are
predominantly transmitted to vertebrates by a mosquito vector. Alphavirus disease in …

Viruses are intracellular parasites that use the host cell they infect to produce new infectious
progeny. Distinct steps of the virus life cycle occur in association with the cytoskeleton or …

Alphaviruses are small, spherical, enveloped, positive-sense ssRNA viruses responsible for
a considerable number of human and animal diseases. Alphavirus members include …

In this review, we summarize the current knowledge about the membranous replication
factories of members of plus-strand (+) RNA viruses. We discuss primarily the architecture of …

Positive-sense single-stranded RNA viruses, such as coronaviruses, flaviviruses and
alphaviruses, carry out transcription and replication inside virus-induced membranous …

The cytoplasmic replication of positive-sense RNA viruses is associated with a dramatic
rearrangement of host cellular membranes. These virus-induced changes result in the …

Coronavirus genome replication and transcription take place at cytoplasmic membranes and
involve coordinated processes of both continuous and discontinuous RNA synthesis that are …

Plus-strand RNA virus replication occurs in tight association with cytoplasmic host cell
membranes. Both, viral and cellular factors cooperatively generate distinct organelle-like …