BACKGROUND: The American Heart Association (AHA), in conjunction with the National
Institutes of Health, annually reports the most up-to-date statistics related to heart disease …

Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

Mendelian randomisation (MR) studies allow a better understanding of the causal effects of
modifiable exposures on health outcomes, but the published evidence is often hampered by …

Large-scale genome-wide association studies conducted over the last decade have
uncovered numerous genetic variants associated with cardiometabolic traits and risk factors …

Evidence on the validity of drug targets from randomized trials is reliable but typically
expensive and slow to obtain. In contrast, evidence from conventional observational …

Background Obesity is a worldwide epidemic that has been associated with a plurality of
diseases in observational studies. The aim of this study was to summarize the evidence from …

Statins are widely used to prevent cardiovascular disease events. Cardiovascular diseases
and type 2 diabetes are tightly connected since type 2 diabetes is a major risk factor for …

Mendelian randomization (MR) is a genetic epidemiological technique that uses genetic
variation to infer causal relationships between modifiable exposures and outcome variables …

Background We investigated the causal associations between the genetic liability to
cardiovascular and lifestyle risk factors and peripheral artery disease (PAD), using a …

Phenotypic heterogeneity at genomic loci encoding drug targets can be exploited by
multivariable Mendelian randomization to provide insight into the pathways by which …