At the nuclear periphery, associations of chromatin with the nuclear lamina through lamina-
associated domains (LADs) aid functional organization of the genome. We review the …

The potential of human induced pluripotent stem cells (iPSCs) to self-renew indefinitely and
to differentiate virtually into any cell type in unlimited quantities makes them attractive for in …

Parkinson's disease (PD) is one of the most common neurodegenerative disorders, which
affects about 0.3% of the general population. As the population in the developed world ages …

Genetic changes acquired during in vitro culture pose a risk for the successful application of
stem cells in regenerative medicine. To assess the genetic risks induced by culturing, we …

Induced pluripotent stem cells (iPSC) technology has propelled the field of stem cells
biology, providing new cells to explore the molecular mechanisms of pluripotency, cancer …

The use of induced Pluripotent Stem Cells (iPSC) as a source of autologous tissues shows
great promise in regenerative medicine. Nevertheless, several major challenges remain to …

To understand the mutational burden of human induced pluripotent stem cells (iPSCs), we
sequenced genomes of 18 fibroblast-derived iPSC lines and identified different classes of …

Abstract In 2006, Shinya Yamanaka generated induced pluripotent stem cells (iPSCs),
which has been the major scientific event of the decade that caught the eye of many …

Human pluripotent stem cells (hPSCs) include human embryonic stem cells (hESCs)
derived from blastocysts and human induced pluripotent stem cells (hiPSCs) generated from …

Induced pluripotent stem cells (iPSCs) offer huge promise and potential in the creation of
patient-specific stem cells for modeling human diseases, drug development and testing, and …