[HTML][HTML] Tyrosine kinase inhibitors for solid tumors in the past 20 years (2001–2020)
L Huang, S Jiang, Y Shi - Journal of hematology & oncology, 2020 - Springer
Tyrosine kinases are implicated in tumorigenesis and progression, and have emerged as
major targets for drug discovery. Tyrosine kinase inhibitors (TKIs) inhibit corresponding …
major targets for drug discovery. Tyrosine kinase inhibitors (TKIs) inhibit corresponding …
[HTML][HTML] Neratinib for HER2-positive breast cancer with an overlooked option
L Guo, W Shao, C Zhou, H Yang, L Yang, Q Cai… - Molecular …, 2023 - Springer
Positive human epidermal growth factor receptor 2 (HER2) expression is associated with an
increased risk of metastases especially those to the brain in patients with advanced breast …
increased risk of metastases especially those to the brain in patients with advanced breast …
The story of EGFR: from signaling pathways to a potent anticancer target
S Ramani, S Samant, SM Manohar - Future Medicinal Chemistry, 2022 - Taylor & Francis
EGFR is a member of the ERBB family. It plays a significant role in cellular processes such
as growth, survival and differentiation via the activation of various signaling pathways. EGFR …
as growth, survival and differentiation via the activation of various signaling pathways. EGFR …
Cardiotoxicity in HER2-positive breast cancer patients
Due to the recent advances in diagnosis and management of patients with HER2-positive
breast cancer, especially through novel HER2-targeted agents, cardiotoxicity becomes an …
breast cancer, especially through novel HER2-targeted agents, cardiotoxicity becomes an …
[HTML][HTML] Recent advancements in the development of anti-breast cancer synthetic small molecules
EB Elkaeed, HAAE Salam, A Sabt, GH Al-Ansary… - Molecules, 2021 - mdpi.com
Among all cancer types, breast cancer (BC) still stands as one of the most serious diseases
responsible for a large number of cancer-associated deaths among women worldwide, and …
responsible for a large number of cancer-associated deaths among women worldwide, and …
[HTML][HTML] Novel receptor tyrosine kinase pathway inhibitors for targeted radionuclide therapy of glioblastoma
J Bolcaen, S Nair, CHS Driver, TMG Boshomane… - Pharmaceuticals, 2021 - mdpi.com
Glioblastoma (GB) remains the most fatal brain tumor characterized by a high infiltration rate
and treatment resistance. Overexpression and/or mutation of receptor tyrosine kinases is …
and treatment resistance. Overexpression and/or mutation of receptor tyrosine kinases is …
[HTML][HTML] Clinico–pathologic factors and survival of patients with breast cancer diagnosed with de novo brain metastasis: a national cancer database analysis
A Hijazi, M Mohanna, S Sabbagh, M Herrán… - Breast Cancer Research …, 2024 - Springer
Abstract Purpose Patients with Breast Cancer (BC) with Brain Metastasis (BCBM) have poor
survival outcomes. We aimed to explore the clinico–pathologic and therapeutic factors …
survival outcomes. We aimed to explore the clinico–pathologic and therapeutic factors …
Receptor tyrosine kinase gene expression profiling of orbital rhabdomyosarcoma unveils MET as a potential biomarker and therapeutic target
S Chauhan, S Sen, K Irshad, S Kashyap, N Pushker… - Human Cell, 2024 - Springer
Receptor tyrosine kinases (RTKs) serve as molecular targets for the development of novel
personalized therapies in many malignancies. In the present study, expression pattern of …
personalized therapies in many malignancies. In the present study, expression pattern of …
[HTML][HTML] Use of HER2-directed therapy in metastatic breast cancer and how community physicians collaborate to improve care
JE Mortimer, L Kruper, M Cianfrocca… - Journal of Clinical …, 2020 - mdpi.com
The development of new HER2-directed therapies has resulted in a significant prolongation
of survival for women with metastatic HER2-positive breast cancer. Discoveries in the …
of survival for women with metastatic HER2-positive breast cancer. Discoveries in the …
Pyridine ring as an important scaffold in anticancer drugs
Pyridine is a chemical scaffold with growing biological importance. Pyridine-based
compounds represent a useful class of heterocycles found in various chemotherapeutic …
compounds represent a useful class of heterocycles found in various chemotherapeutic …