Pancreatic β‐cell death, regeneration and insulin secretion: Roles of poly (ADP‐ribose) polymerase and cyclic ADP‐ribose
S Takasawa, H Okamoto - Journal of Diabetes Research, 2002 - Wiley Online Library
In the early 1980s, we proposed a unifying model for β‐cell damage (The OKAMOTO
model), in which poly (ADP‐ribose) synthetase/polymerase (PARP) activation plays an …
model), in which poly (ADP‐ribose) synthetase/polymerase (PARP) activation plays an …
Physiological and pathological significance of the CD38-cyclic ADP-ribose signaling system
H Okamoto, S Takasawa, K Nata, I Kato… - Human CD38 and …, 2000 - karger.com
Glucose induces an increase in the intracellular Ca2+ concentration in pancreatic-cells of
the islets of Langerhans to secrete insulin. Since 1984, this increase in the Ca2+ …
the islets of Langerhans to secrete insulin. Since 1984, this increase in the Ca2+ …
Tacrolimus severe overdosage after intake of masked grapefruit in orange marmalade
D Peynaud, B Charpiat, T Vial, M Gallavardin… - European journal of …, 2007 - Springer
Since the initial paper of Bailey [1] describing interactions of grapefruit with nifedipine and
felodipine, a number of interactions have been reported with other drugs, including …
felodipine, a number of interactions have been reported with other drugs, including …
Multicenter prospective investigation on cardiovascular adverse effects of tacrolimus in kidney transplantations
Y Seino, M Hori, T Sonoda - Cardiovascular drugs and therapy, 2003 - Springer
To clarify the incidence and pathophysiological mechanism of cardiovascular adverse
effects of tacrolimus, the present prospective study performed scheduled cardiovascular …
effects of tacrolimus, the present prospective study performed scheduled cardiovascular …
The CD38-Cyclic ADP-Ribose Signal System in Pancreatic ß-Cells: The Discovery and Biological Significance of a Novel Signal System in Mammalian Cells
S Takasawa, H Okamoto - Cyclic ADP-Ribose and NAADP: Structures …, 2002 - Springer
In the early 1980's, we showed that maintenance of the cellular NAD+ level in β-cells of the
islets of Langerhans is essential for the synthesis and secretion of insulin, and proposed a …
islets of Langerhans is essential for the synthesis and secretion of insulin, and proposed a …
薬理学の新世紀を拓く“The CD38‐cyclic ADP‐ribose signal system” その分子機構と医学・生物学上の意義
岡本宏 - 日本薬理学雑誌, 1999 - jlc.jst.go.jp
1. Aims 本稿 で は cyclicADP 一 リボース (cADPR) が 関与す る新しい情報伝達系 TheCD38 一
(ADPRsignalsystem に ついて, 先 ず, 最 初 に我 々が この系 に取 り組 んだ経 緯 につ いて, 次に …
(ADPRsignalsystem に ついて, 先 ず, 最 初 に我 々が この系 に取 り組 んだ経 緯 につ いて, 次に …
“TheCD38―cyclic ADP-ribose signal system”: その分子機構と医学・生物学上の意義薬理学の新世紀を拓く
岡本宏 - 日本薬理学雑誌, 1999 - jstage.jst.go.jp
1. Aims 本稿 で は cyclicADP 一 リボース (cADPR) が 関与す る新しい情報伝達系 TheCD38 一
(ADPRsignalsystem に ついて, 先 ず, 最 初 に我 々が この系 に取 り組 んだ経 緯 につ いて, 次に …
(ADPRsignalsystem に ついて, 先 ず, 最 初 に我 々が この系 に取 り組 んだ経 緯 につ いて, 次に …