Importance Malignant primary brain tumors cause more than 15 000 deaths per year in the
United States. The annual incidence of primary malignant brain tumors is approximately 7 …

Isocitrate dehydrogenase (IDH) mutant gliomas are the most common adult, malignant
primary brain tumors diagnosed in patients younger than 50, constituting an important cause …

Background Gliomas are the most common primary malignant brain tumor. Diffuse low-
grade and intermediate-grade gliomas, which together compose the lower-grade gliomas …

Gliomas are a diverse group of primary central nervous system tumors that affect both
children and adults. Recent studies have revealed a dynamic cross talk that occurs between …

Background Glioma patients suffer from a wide range of symptoms which influence quality of
life negatively. The aim of this review is to give an overview of symptoms most prevalent in …

Seizures are a frequent complication of adult-type diffuse gliomas, and are often difficult to
control with medications. Gliomas with mutations in isocitrate dehydrogenase 1 or 2 …

Cancer cells are abnormal cells that can reproduce and regenerate rapidly. They are
characterized by unlimited proliferation, transformation and migration, and can destroy …

Background Age is associated with the prognosis of glioma patients, but there is no uniform
standard of age-group classification to evaluate the prognosis of glioma patients. In this …

Background Uncontrolled seizures in patients with gliomas have a significant impact on
quality of life and morbidity, yet the mechanisms through which these tumors cause seizures …

The finding that most grades II and III gliomas harbor isocitrate dehydrogenase (IDH)
mutations conveying a relatively favorable and fairly similar prognosis in both tumor grades …