Co-amorphous drug delivery systems (CAMS) are characterized by the combination of two
or more (initially crystalline) low molecular weight components that form a homogeneous …

The amorphous solid state offers an improved apparent solubility and dissolution rate.
However, due to thermodynamic instability and recrystallization tendencies during …

In recent years, the coamorphous drug delivery system has been established as a promising
formulation approach for delivering poorly water-soluble drugs. The coamorphous solid is a …

Buccal mucosal membrane offers an attractive drug-delivery route to enhance both systemic
and local therapy. This review discusses the benefits and drawbacks of buccal drug delivery …

Amorphous solid dispersions (ASDs) improve the oral delivery of poorly water-soluble
drugs. ASDs of olanzapine (OLZ), which have a high melting point and low solubility, are …

Paroxetine (PX) is the most potent serotonin reuptake inhibitor utilized in depression and
anxiety treatment. It has drawbacks, such as having a very bitter taste, low water solubility …

Warfarin is a narrow therapeutic index drug that requires personalized dosing which is
currently not achieved by the marketed products. Further, pediatric and geriatric patients …

Introduction Most new drug candidates under development are poorly water-soluble, which
are related to multiple pharmaceutical issues, increasing the bioavailability of these drugs by …

Highlights•Orodisperisible dosage forms improve the patient's compliance and/or
adherence.•Bioavailability must take in consideration the possible pre-gastric …

Binary co-amorphous systems (CAMS) are a type of solid dispersion containing an active
pharmaceutical ingredient (API) and small molecule excipients. The properties of these …