Oxidative stress is proposed as a regulatory element in ageing and various neurological
disorders. The excess of oxidants causes a reduction of antioxidants, which in turn produce …

Over the past decade, it has become clear that lipid homeostasis is central to cellular
metabolism. Lipids are particularly abundant in the central nervous system (CNS) where …

The brain is the most complex human organ, consuming more energy than any other tissue
in proportion to its size. It relies heavily on mitochondria to produce energy and is made up …

A decline in energy is common in aging, and the restoration of mitochondrial bioenergetics
may offer a common approach for the treatment of numerous age‐associated diseases …

Mitochondria, long viewed solely in the context of bioenergetics, are increasingly emerging
as critical hubs for intracellular signaling. Due to their bacterial origin, mitochondria possess …

Mitochondrial dysfunctions caused by oxidative stress are currently regarded as the main
cause of aging. Accumulation of mutations and deletions of mtDNA is a hallmark of aging …

Aging is a biological process characterized by impairment of cellular bioenergetic function,
increased oxidative stress, attenuated ability to respond to stresses, increased risk of …

Significance: Mitochondria are fundamental to the life and proper functioning of cells. These
organelles play a key role in energy production, in maintaining homeostatic levels of second …

Aging is a natural, complex, and multifactorial biological process associated with impairment
of bioenergetic function, increased oxidative stress, attenuated ability to respond to stresses …

Recent evidence has demonstrated that insulin resistance is related to the development of
type 2 diabetes mellitus. Our previous study found that high-fat diet (HFD) consumption …