Posaconazole is typically used for preventing invasive yeast and mold infections such as
invasive aspergillosis in high-risk immunocompromised patients. The oral suspension was …

Model‐informed drug development (MIDD) has a long and rich history in infectious
diseases. This review describes foundational principles of translational anti‐infective …

Antibiotic resistance presents an incessant threat to our drug armamentarium that
necessitates novel approaches to therapy. Over the past several decades, investigation of …

Pharmacokinetic/pharmacodynamic (PKPD) models have emerged as valuable tools for the
characterization and translation of antibiotic effects, and consequently for drug development …

Background Digitalization and artificial intelligence have an important impact on the way
microbiology laboratories will work in the near future. Opportunities and challenges lie …

The evolution of antimicrobial resistance can be strongly affected by variations of
antimicrobial concentration. Here, we study the impact of periodic alternations of absence …

Background Reviews assessing the genetic basis of ciprofloxacin resistance in Escherichia
coli have mostly been qualitative. However, to predict resistance phenotypes based on …

The value of model‐based translation in drug discovery and development is now effectively
being recognized in many disease areas and among various stakeholders. Such …

Objectives Mycobacterium tuberculosis can exist in different states in vitro, which can be
denoted as fast multiplying, slow multiplying and non-multiplying. Characterizing the natural …

Elizabethkingia anophelis has emerged as a critical human pathogen, and a number of
isolated reports have described the successful treatment of Elizabethkingia infections with …