Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …

Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a
formalized, transparent and quality-controlled way, mechanistic information to apical …

In 2016, the Frank R. Lautenberg Chemical Safety for the 21st Century Act became the first
US legislation to advance chemical safety evaluations by utilizing novel testing approaches …

Green chemistry seeks to design less hazardous chemicals, but many of the efforts to
replace chemicals have resulted in so-called “Regrettable Substitutions”, when a chemical …

There is a paucity of information concerning the developmental neurotoxicity (DNT) hazard
posed by industrial and environmental chemicals. New testing approaches will most likely …

Neurotoxicity and developmental neurotoxicity are important issues of chemical hazard
assessment. Since the interpretation of animal data and their extrapolation to man is …

Systems Toxicology aims to change the basis of how adverse biological effects of
xenobiotics are characterized from empirical end points to describing modes of action as …

Complementing the human genome with an exposome reflects the increasingly obvious
impact of environmental exposure, which far exceeds the role of genetics, on human health …

Common recommendations for cell line authentication, annotation and quality control fall
short addressing genetic heterogeneity. Within the Human Toxome Project, we demonstrate …

Most late model high-resolution mass spectrometers (HRMS) are capable of performing
sensitive and reliable quantifications of a large variety of analytes in global HR-full scan (HR …