Sphingosine 1-phosphate modulation and immune cell trafficking in inflammatory bowel disease
Immune cell trafficking is a critical element of the intestinal immune response, both in
homeostasis and in pathological conditions associated with inflammatory bowel disease …
homeostasis and in pathological conditions associated with inflammatory bowel disease …
Mammalian G proteins and their cell type specific functions
N Wettschureck, S Offermanns - Physiological reviews, 2005 - journals.physiology.org
Heterotrimeric G proteins are key players in transmembrane signaling by coupling a huge
variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple …
variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple …
Chemokines in Innate and Adaptive Host Defense: Basic Chemokinese Grammar for Immune Cells
A Rot, UH Von Andrian - Annu. Rev. Immunol., 2004 - annualreviews.org
▪ Abstract Chemokines compose a sophisticated communication system used by all our cell
types, including immune cells. Chemokine messages are decoded by specific receptors that …
types, including immune cells. Chemokine messages are decoded by specific receptors that …
The alliance of sphingosine-1-phosphate and its receptors in immunity
J Rivera, RL Proia, A Olivera - Nature Reviews Immunology, 2008 - nature.com
Abstract Sphingosine-1-phosphate (S1P) is a biologically active metabolite of plasma-
membrane sphingolipids that is essential for immune-cell trafficking. Its concentration is …
membrane sphingolipids that is essential for immune-cell trafficking. Its concentration is …
Lysophospholipid receptors: signaling and biology
▪ Abstract Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine 1-
phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental …
phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental …
Altered lipid metabolism in brain injury and disorders
RM Adibhatla, JF Hatcher - Lipids in health and disease, 2008 - Springer
Deregulated lipid metabolism may be of particular importance for CNS injuries and
disorders, as this organ has the highest lipid concentration next to adipose tissue …
disorders, as this organ has the highest lipid concentration next to adipose tissue …
Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils
J Xu, F Wang, A Van Keymeulen, P Herzmark… - Cell, 2003 - cell.com
Like neutrophilic leukocytes, differentiated HL-60 cells respond to chemoattractant by
adopting a polarized morphology, with F-actin in a protruding pseudopod at the leading …
adopting a polarized morphology, with F-actin in a protruding pseudopod at the leading …
[HTML][HTML] Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a “come-and-get-me” signal
DR Gude, SE Alvarez, SW Paugh, P Mitra… - The FASEB …, 2008 - ncbi.nlm.nih.gov
Abstract Sphingosine-1-phosphate (S1P) is a bioactive lipid that regulates myriad important
cellular processes, including growth, survival, cytoskeleton rearrangements, motility, and …
cellular processes, including growth, survival, cytoskeleton rearrangements, motility, and …
Structure of S1PR2–heterotrimeric G13 signaling complex
Sphingosine-1-phosphate (S1P) regulates immune cell trafficking, angiogenesis, and
vascular function via its five receptors. Inherited mutations in S1P receptor 2 (S1PR2) occur …
vascular function via its five receptors. Inherited mutations in S1P receptor 2 (S1PR2) occur …