Simple Summary When tumors become resistant to chemotherapeutics, alternative
treatment strategies must be explored. Gene targeting provides a personalized and …

Genomic instability is a hallmark of cancer and a common feature of human disorders,
characterized by growth defects, neurodegeneration, cancer predisposition, and aging …

The compaction of chromatin into mitotic chromosomes is essential for faithful transmission
of the genome during cell division. In eukaryotes, chromosome morphogenesis is regulated …

DNA replication initiates from multiple origins, and selective CDC7 kinase inhibitors
(CDC7is) restrain cell proliferation by limiting origin firing. We have performed a CRISPR …

In preparation for dramatic morphogenetic events of gastrulation, rapid embryonic cell cycles
slow at the mid-blastula transition (MBT). In Drosophila melanogaster embryos, down …

Abstract The Tousled-like kinases (TLKs) are an evolutionarily conserved family of serine–
threonine kinases that have been implicated in DNA replication, DNA repair, transcription …

Embryonic stem cells (ESCs), somatic cell nuclear transfer ESCs, and induced pluripotent
stem cells (iPSCs) represent the most studied group of PSCs. Unlimited self-renewal without …

In yeast, Rif1 is part of the telosome, where it inhibits telomerase and checkpoint signaling at
chromosome ends. In mammalian cells, Rif1 is not telomeric, but it suppresses DNA end …

Rif1 is involved in telomere homeostasis, DNA replication timing, and DNA double-strand
break (DSB) repair pathway choice from yeast to human. The molecular mechanisms that …

Simple Summary The increasingly wide use of PARP inhibitors in breast, ovarian,
pancreatic, and prostate cancers harbouring a pathogenic variant in BRCA1 or BRCA2 has …