Multiplexed imaging in oncology

C Andreou, R Weissleder, MF Kircher - Nature Biomedical Engineering, 2022 - nature.com
In oncology, technologies for clinical molecular imaging are used to diagnose patients,
establish the efficacy of treatments and monitor the recurrence of disease. Multiplexed …

NIR TADF emitters and OLEDs: challenges, progress, and perspectives

Y Xiao, H Wang, Z Xie, M Shen, R Huang, Y Miao… - Chemical …, 2022 - pubs.rsc.org
Near-infrared (NIR) light-emitting materials show excellent potential applications in the fields
of military technology, bioimaging, optical communication, organic light-emitting diodes …

Surface nanopore engineering of 2D MXenes for targeted and synergistic multitherapies of hepatocellular carcinoma

Z Li, H Zhang, J Han, Y Chen, H Lin… - Advanced …, 2018 - Wiley Online Library
Hepatocellular carcinoma (HCC) is one of the most common and deadly gastrointestinal
malignancies. Given its insensitivity to traditional systematic chemotherapy, new therapeutic …

Porphyrin as diagnostic and therapeutic agent

N Tsolekile, S Nelana, OS Oluwafemi - Molecules, 2019 - mdpi.com
The synthesis and application of porphyrins has seen a huge shift towards research in
porphyrin bio-molecular based systems in the past decade. The preferential localization of …

Activatable probes for diagnosing and positioning liver injury and metastatic tumors by multispectral optoacoustic tomography

Y Wu, S Huang, J Wang, L Sun, F Zeng… - Nature Communications, 2018 - nature.com
Optoacoustic tomography (photoacoustic tomography) is an emerging imaging technology
displaying great potential for medical diagnosis and preclinical research. Rationally …

Activatable small‐molecule photoacoustic probes that cross the blood–brain barrier for visualization of copper (II) in mice with Alzheimer's disease

S Wang, Z Sheng, Z Yang, D Hu, X Long… - Angewandte Chemie …, 2019 - Wiley Online Library
Copper enrichment in the brain is highly related to Alzheimer's disease (AD) pathogenesis,
but in vivo tracing of Cu2+ in the brain by imaging techniques is still a great challenge. In this …

Molecular photoacoustic contrast agents: design principles & applications

RE Borg, J Rochford - Photochemistry and photobiology, 2018 - Wiley Online Library
Photoacoustic imaging (PAI) is a rapidly growing field which offers high spatial resolution
and high contrast for deep‐tissue imaging in vivo. PAI is nonionizing and noninvasive and …

Manganese (II) texaphyrin: a paramagnetic photoacoustic contrast agent activated by near-IR light

Y Ren, AC Sedgwick, J Chen, G Thiabaud… - Journal of the …, 2020 - ACS Publications
The NIR absorptivity of the metallotexaphyrin derivatives MMn, MGd, and MLu for
photoacoustic (PA)-based imaging is explored in this study. All three complexes …

Diagnosing drug-induced liver injury by multispectral optoacoustic tomography and fluorescence imaging using a leucine-aminopeptidase-activated probe

Y Huang, Y Qi, C Zhan, F Zeng, S Wu - Analytical chemistry, 2019 - ACS Publications
Drug-induced liver injury (DILI) is a frequent cause of hepatic dysfunction as well as the
single most frequent reason for removing approved medications from the market, and …

Metal complexes and nanoparticles for photoacoustic imaging

A Steinbrueck, J Karges - ChemBioChem, 2023 - Wiley Online Library
Clinical imaging techniques are widely used to detect, locate, and track the growth or
shrinkage of cancerous tumors. Although these techniques have shown impressive results …