Supramolecular peptide nanofiber hydrogels for bone tissue engineering: from multihierarchical fabrications to comprehensive applications

Z Hao, H Li, Y Wang, Y Hu, T Chen, S Zhang… - Advanced …, 2022 - Wiley Online Library
Bone tissue engineering is becoming an ideal strategy to replace autologous bone grafts for
surgical bone repair, but the multihierarchical complexity of natural bone is still difficult to …

Recent trends in the development of peptide and protein-based hydrogel therapeutics for the healing of CNS injury

N Mukherjee, A Adak, S Ghosh - Soft Matter, 2020 - pubs.rsc.org
Traumatic brain injury (TBI) and spinal cord injury (SCI) cause millions of deaths and
permanent or prolonged physical disabilities around the globe every year. It generally …

Natural tripeptide-based inhibitor of multifaceted amyloid β toxicity

K Rajasekhar, C Madhu… - ACS chemical …, 2016 - ACS Publications
Accumulation of amyloid beta (Aβ) peptide and its aggregates in the human brain is
considered as one of the hallmarks of Alzheimer's disease (AD). The polymorphic oligomers …

Small molecule inhibits metal-dependent and-independent multifaceted toxicity of Alzheimer's disease

S Samanta, K Rajasekhar, V Babagond… - ACS Chemical …, 2019 - ACS Publications
Alzheimer's disease (AD) is one of the most devastating forms of dementia, without reliable
treatments to cure, delay the onset, or prevent the disease progression. The proposed toxic …

Biodegradable neuro-compatible peptide hydrogel promotes neurite outgrowth, shows significant neuroprotection, and delivers anti-Alzheimer drug

A Adak, G Das, S Barman, S Mohapatra… - … Applied Materials & …, 2017 - ACS Publications
A novel neuro-compatible peptide-based hydrogel has been designed and developed,
which contains microtubule stabilizing and neuroprotective short peptide. This hydrogel …

Biocompatible lipopeptide-based antibacterial hydrogel

A Adak, S Ghosh, V Gupta, S Ghosh - Biomacromolecules, 2019 - ACS Publications
A biocompatible hydrogel containing a hexapeptide as a key unit has been designed and
fabricated. Our design construct comprises a β-sheet-rich short hexapeptide in the center …

Mechanistic insights into the mitigation of Aβ aggregation and protofibril destabilization by ad-enantiomeric decapeptide rk10

K Singh, A Kaur, D Goyal, B Goyal - Physical Chemistry Chemical …, 2022 - pubs.rsc.org
According to clinical studies, the development of Alzheimer's disease (AD) is linked to the
abnormal aggregation of amyloid-β (Aβ) peptides into toxic soluble oligomers, protofibrils as …

An overview of latest advances in exploring bioactive peptide hydrogels for neural tissue engineering

P Sharma, VK Pal, S Roy - Biomaterials Science, 2021 - pubs.rsc.org
Neural tissue engineering holds great potential in addressing current challenges faced by
medical therapies employed for the functional recovery of the brain. In this context, self …

Glycosides and their corresponding small molecules inhibit aggregation and alleviate cytotoxicity of Aβ40

S Hao, Y Yang, A Han, J Chen, X Luo… - ACS Chemical …, 2022 - ACS Publications
Polyphenols are the class of naturally synthesized compounds in the secondary metabolism
of plants, which are widely distributed in fruits and vegetables. Their potential health …

Extracellular Matrix (ECM)-mimicking neuroprotective injectable sulfo-functionalized peptide hydrogel for repairing brain injury

A Adak, G Das, J Khan, N Mukherjee… - ACS Biomaterials …, 2020 - ACS Publications
Brain injury can lead to the loss of neuronal functions and connections, along with the
damage of the extracellular matrix (ECM). Thus, it ultimately results in devastating long-term …