[HTML][HTML] HIV in pregnancy: Mother-to-child transmission, pharmacotherapy, and toxicity

L Cerveny, P Murthi, F Staud - … et Biophysica Acta (BBA)-Molecular Basis of …, 2021 - Elsevier
An estimated 1.3 million pregnant women were living with HIV in 2018. HIV infection is
associated with adverse pregnancy outcomes and all HIV-positive pregnant women …

Perinatal genotoxicity and carcinogenicity of anti-retroviral nucleoside analog drugs

MC Poirier, OA Olivero, DM Walker… - Toxicology and applied …, 2004 - Elsevier
The current worldwide spread of the human immunodeficiency virus-1 (HIV-1) to the
heterosexual population has resulted in approximately 800000 children born yearly to HIV-1 …

Inhibition of telomerase activity by human immunodeficiency virus (HIV) nucleos (t) ide reverse transcriptase inhibitors: a potential factor contributing to HIV-associated …

E Leeansyah, PU Cameron, A Solomon… - The Journal of …, 2013 - academic.oup.com
Background. Human immunodeficiency virus (HIV)-infected patients on combination active
antiretroviral therapy (cART) are at increased risk of age-related complications. We …

Long-term mitochondrial toxicity in HIV-uninfected infants born to HIV-infected mothers

MC Poirier, RL Divi, L Al-Harthi… - JAIDS Journal of …, 2003 - journals.lww.com
Although children born to HIV-infected (HIV+) women receiving antiretroviral therapy during
pregnancy show virtually no adverse clinical effects at birth, the antiretroviral nucleoside …

Perinatal antiretroviral treatment and hematopoiesis in HIV-uninfected infants

J Le Chenadec, MJ Mayaux, C Guihenneuc-Jouyaux… - Aids, 2003 - journals.lww.com
Background: The perinatal prophylactic administration of zidovudine is associated with
rapidly reversible macrocytic anemia in infants. However, a recent study suggests that there …

Decreased semen volume and spermatozoa motility in HIV‐1‐infected patients under antiretroviral treatment

L Bujan, M Sergerie, N Moinard, S Martinet… - Journal of …, 2007 - Wiley Online Library
Inconsistent results have been reported for the semen quality in HIV‐infected men, due to
the biases inherent in some studies. The objective of the present study was to investigate the …

Active transport across the human placenta: impact on drug efficacy and toxicity

D Evseenko, JW Paxton, JA Keelan - Expert opinion on drug …, 2006 - Taylor & Francis
The human placenta expresses a large number of transport proteins. The ATP-binding
cassette (ABC) family of active efflux pumps, predominantly localised to the maternal-facing …

Mother-to-child transmission of HIV infection and its prevention

C Thorne, ML Newell - Current HIV research, 2003 - ingentaconnect.com
An estimated 800,000 children acquired HIV-infection in 2002, most as a result of mother-to-
child transmission (MTCT), and vertically-acquired HIV infection continues to be of major …

Safety of agents used to prevent mother-to-child transmission of HIV: is there any cause for concern?

C Thorne, ML Newell - Drug Safety, 2007 - Springer
Antiretroviral drugs have been used routinely to reduce the risk of mother-to-child
transmission of HIV infection since 1994, following the AIDS Clinical Trials Group 076 trial …

Mitochondrial damage and DNA depletion in cord blood and umbilical cord from infants exposed in utero to Combivir

RL Divi, VE Walker, NA Wade, K Nagashima… - Aids, 2004 - journals.lww.com
Objective: Although most uninfected infants born to women infected with HIV-1 show no
clinical evidence of mitochondrial compromise, mitochondrial dysfunction has been reported …