Lipid droplets are dynamic intracellular lipid storage organelles that respond to the
physiological state of cells. In addition to controlling cell metabolism, they play a protective …

Macrophages destroy bacteria and other microorganisms through phagocytosis-coupled
antimicrobial responses, such as the generation of reactive oxygen species and the delivery …

Non-neuronal cells are key to the complex cellular interplay that follows central nervous
system insult. To understand this interplay, we generated a single-cell atlas of immune, glial …

Caveolin-1 (CAV1) and CAV3 are membrane-sculpting proteins driving the formation of the
plasma membrane (PM) caveolae. Within the PM mosaic environment, caveola assembly is …

In the ongoing conflict between eukaryotic cells and pathogens, lipid droplets (LDs) emerge
as a choke point in the battle for nutrients. While many pathogens seek the lipids stored in …

The E4 variant of APOE strongly predisposes individuals to late-onset Alzheimer's disease.
We demonstrate that in response to lipogenesis, apolipoprotein E (APOE) in astrocytes can …

Metabolism in host cells can be modulated after viral infection, favoring viral survival or
clearance. Here, we report that lipid droplet (LD) synthesis in host cells can be modulated by …

Lipid droplets (LDs) consist of a core of neutral lipids such as triacylglycerols and cholesteryl
esters covered by a phospholipid monolayer. Recent studies have shown that LDs not only …

ABSTRACT Interferon-stimulated gene 15 (ISG15) is a 15-kDa ubiquitin-like modifier that
binds to target proteins in a process termed ISGylation. ISG15, first described as an antiviral …

We report here two genome-wide CRISPR screens performed to identify genes that, when
knocked out, alter levels of lysosomal cholesterol or bis (monoacylglycero) phosphate. In …