Breast cancer is the most frequently diagnosed cancer and the principal cause of mortality
by malignancy in women and represents a main problem for public health worldwide. Tumor …

A20, also known as TNFAIP3, is a potent regulator of ubiquitin (Ub) dependent signals. A20
prevents multiple human diseases, indicating that the critical functions of this protein are …

The high frequency of breast cancer worldwide and the high mortality among women with
this malignancy are a serious challenge for modern medicine. A deeper understanding of …

Background Non-alcoholic fatty liver disease (NAFLD) has a high incidence and mortality
rate, and a rapid course of clinical development. Although miR-125b is closely associated …

Deubiquitylating enzymes (DUBs) are proteases that remove the ubiquitin moiety from
ubiquitylated substrates to antagonize the modification mediated by E3 ubiquitin ligases …

Aminoacyl-tRNA synthetases (ARSs) are an important class of enzymes with an
evolutionarily conserved mechanism for protein synthesis. In higher eukaryotic systems …

A20 is a prototypical anti-inflammatory molecule that is linked to multiple human diseases,
including cancers. The role of A20 as a tumor suppressor was first discovered in B cell …

Breast cancer has become the malignant tumor with the first incidence and the second
mortality among female cancers. Most female breast cancers belong to luminal-type breast …

Pyroptosis is a gasdermin-mediated pro-inflammatory form of programmed cell death (PCD).
Tumor necrosis factor-ɑ (TNF-ɑ) is an inflammatory cytokine, and some studies have shown …

Regarding the multimechanistic nature of cancers, current chemo‐or radiotherapies often
fail to eradicate disease pathology, and frequent relapses or resistance to therapies occur …