Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …

Hematopoietic stem cells (HSCs), which govern the production of all blood lineages,
transition through a series of functional states characterized by expansion during fetal …

PURPOSE Clonal hematopoiesis (CH) can be transmitted from a donor to a recipient during
allogeneic hematopoietic cell transplantation. Exclusion of candidate donors with CH is …

Hematopoietic stem cell (HSC) self-renewal and aging are tightly regulated by paracrine
factors from the bone marrow niche. However, whether HSC rejuvenation could be achieved …

Mesenchymal stem cells (MSCs) possess potent immunomodulatory activity and have been
extensively investigated for their therapeutic potential in treating inflammatory disorders …

Stem cells play central roles in tissue development, homeostasis, and regeneration.
Decades of scientific research have uncovered processes of stem cell decline in tissue and …

Blood production depends on rare haematopoietic stem cells (HSCs) and haematopoietic
stem and progenitor cells (HSPCs) that ultimately take up residence in the bone marrow …

Maintaining proteostasis is key to resisting stress and promoting healthy aging. Proteostasis
is necessary to preserve stem cell function, but little is known about the mechanisms that …

Clonal hematopoiesis resulting from the enhanced fitness of mutant hematopoietic stem
cells (HSC) associates with both favorable and unfavorable health outcomes related to the …

Aging facilitates the expansion of hematopoietic stem cells (HSCs) carrying clonal
hematopoiesis-related somatic mutations and the development of myeloid malignancies …