Ways of assembling complex natural products on modular nonribosomal peptide synthetases
HD Mootz, D Schwarzer, MA Marahiel - ChemBioChem, 2002 - Wiley Online Library
Nonribosomal peptide synthetases (NRPSs) catalyze the assembly of a large number of
complex peptide natural products, many of which display therapeutically useful activity. Each …
complex peptide natural products, many of which display therapeutically useful activity. Each …
Hybrid peptide–polyketide natural products: biosynthesis and prospects toward engineering novel molecules
The structural and catalytic similarities between modular nonribosomal peptide synthetase
(NRPS) and polyketide synthase (PKS) inspired us to search for hybrid NRPS–PKS systems …
(NRPS) and polyketide synthase (PKS) inspired us to search for hybrid NRPS–PKS systems …
Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution
Background Non-ribosomal peptide synthetases (NRPSs) are large multimodular enzymes
that synthesize a wide range of biologically active natural peptide compounds, of which …
that synthesize a wide range of biologically active natural peptide compounds, of which …
Surfactin and Other Lipopeptides from Bacillus spp.
P Jacques - Biosurfactants: from genes to applications, 2011 - Springer
Isolated during 1950s and 1960s, the group of lipopeptides from Bacillus spp. gather more
than 30 different peptides linked to various fatty acid chains. More than a 100 different …
than 30 different peptides linked to various fatty acid chains. More than a 100 different …
The mycosubtilin synthetase of Bacillus subtilis ATCC6633: A multifunctional hybrid between a peptide synthetase, an amino transferase, and a fatty acid synthase
EH Duitman, LW Hamoen… - Proceedings of the …, 1999 - National Acad Sciences
Bacillus subtilis strain ATCC6633 has been identified as a producer of mycosubtilin, a potent
antifungal peptide antibiotic. Mycosubtilin, which belongs to the iturin family of lipopeptide …
antifungal peptide antibiotic. Mycosubtilin, which belongs to the iturin family of lipopeptide …
Cloning, sequencing, and characterization of the iturin A operon
K Tsuge, T Akiyama, M Shoda - Journal of bacteriology, 2001 - Am Soc Microbiol
Bacillus subtilis RB14 is a producer of the antifungal lipopeptide iturin A. Using a
transposon, we identified and cloned the iturin A synthetase operon of RB14, and the …
transposon, we identified and cloned the iturin A synthetase operon of RB14, and the …
Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteria
The metabolic repertoire in nature is augmented by generating hybrid metabolites from a
limited set of gene products,,. In mycobacteria, several unique complex lipids are produced …
limited set of gene products,,. In mycobacteria, several unique complex lipids are produced …
Structural and functional organization of the fengycin synthetase multienzyme system from Bacillus subtilis b213 and A1/3
S Steller, D Vollenbroich, F Leenders, T Stein… - Chemistry & biology, 1999 - cell.com
Background Bacillus subtilis strains produce a broad spectrum of lipopeptides that are
potent biosurfactants and have specific antimicrobial and antiviral activities. The cyclic …
potent biosurfactants and have specific antimicrobial and antiviral activities. The cyclic …
Cassava wastewater valorization for the production of biosurfactants: surfactin, rhamnolipids, and mannosileritritol lipids
VK de Oliveira Schmidt, GMD de Vasconscelos… - World Journal of …, 2023 - Springer
The global production of cassava was estimated at ca. 303 million tons. Due to this high
production, the cassava processing industry (cassava flour and starch) generates …
production, the cassava processing industry (cassava flour and starch) generates …
Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an …
J Piel, C Hertweck, PR Shipley, DM Hunt… - Chemistry & biology, 2000 - cell.com
Background: Polycyclic aromatic polyketides, such as the tetracyclines and anthracyclines,
are synthesized by bacterial aromatic polyketide synthases (PKSs). Such PKSs contain a …
are synthesized by bacterial aromatic polyketide synthases (PKSs). Such PKSs contain a …