Abstract Cushing's disease (CD), or pituitary-dependent Cushing's syndrome, is a severe
endocrine disease caused by a corticotroph pituitary tumor and associated with increased …

Cushing's syndrome results from lengthy and inappropriate exposure to excessive
glucocorticoids. Untreated, it has significant morbidity and mortality. The syndrome remains …

Recent years have seen significant advances in our understanding of the development and
function of the adrenal gland together with further insights into the physiologic and …

Cushing's syndrome (CS) patients have increased mortality primarily due to cardiovascular
events induced by glucocorticoid (GC) excess-related severe metabolic changes. Glucose …

Alzheimer's disease (AD) is characterized by the deposition of β-amyloid within the brain
parenchyma and is accompanied by the impairment of neuronal metabolism and function …

Diabetes mellitus is a frequent complication of Cushing syndrome (CS) which is caused by
chronic exposure to glucocorticoid excess, either endogenous or exogenous, and that is …

Cushing's syndrome is a rare endocrine disease characterized by cortisol hypersecretion,
induced mainly by a pituitary tumor (Cushing's disease) or, rarely, by an adrenal or an …

An impaired glucose metabolism, which often leads to the onset of diabetes mellitus (DM), is
a common complication of chronic exposure to exogenous and endogenous glucocorticoid …

Cushing's syndrome can be exogenous, resulting from the administration of glucocorticoids
or adrenocorticotrophic hormone (ACTH), or endogenous, secondary to increased secretion …

Context Although transsphenoidal surgery remains the first-line treatment in Cushing's
disease (CD), recurrence is observed in about 20% of cases. Adjunctive treatments each …