FOXP1 is ubiquitously expressed in the human body and is implicated in both physiological
and pathological processes including cancer. However, despite its importance the role of …

CD4+ T cells are critical regulators of immune responses, but their functional role in human
breast cancer is relatively unknown. The goal of this study was to produce an image of CD4+ …

Hypereosinophilic syndromes (HESs) are rare disorders characterized by marked
hypereosinophilia that is directly responsible for organ damage or dysfunction. Different …

The cell of origin and the tumor microenvironment's role remain elusive for the most common
peripheral T-cell lymphomas (PTCLs). As macrophages promote the growth and survival of …

Early regulators of disease may increase understanding of disease mechanisms and serve
as markers for presymptomatic diagnosis and treatment. However, early regulators are …

Eosinophils are bone marrow-derived cells that infiltrate skin and mucous membrane in a
broad spectrum of primary and reactive inflammatory diseases and malignancies. The …

Angioimmunoblastic T-cell lymphoma (AITL) often shows systemic symptoms related to
immune dysregulation and cytokine production. Biopsy usually harbors few malignant cells …

Lymphocytic variant is a rare subtype of hypereosinophilic syndrome (L-HES) secondary to
overproduction of eosinophilopoietic cytokines by the underlying clonal T lymphocytes with …

Hypereosinophilic syndromes are a group of disorders characterized by persistent and
marked hypereosinophilia not due to an underlying disease known to cause eosinophil …

Abstract The CD3− CD4+ lymphoid variant of hypereosinophilic syndrome is characterized
by hypereosinophilia and clonal circulating CD3− CD4+ T cells. Peripheral T-cell lymphoma …