ERK: a double-edged sword in cancer. ERK-dependent apoptosis as a potential therapeutic strategy for cancer
R Sugiura, R Satoh, T Takasaki - Cells, 2021 - mdpi.com
The RAF/MEK/ERK signaling pathway regulates diverse cellular processes as exemplified
by cell proliferation, differentiation, motility, and survival. Activation of ERK1/2 generally …
by cell proliferation, differentiation, motility, and survival. Activation of ERK1/2 generally …
Flow cytometry: principles, applications and recent advances
SM Manohar, P Shah, A Nair - Bioanalysis, 2021 - Taylor & Francis
Flow cytometry (FCM) is a sophisticated technique that works on the principle of light
scattering and fluorescence emission by the specific fluorescent probe-labeled cells as they …
scattering and fluorescence emission by the specific fluorescent probe-labeled cells as they …
[HTML][HTML] MEK1 is required for PTEN membrane recruitment, AKT regulation, and the maintenance of peripheral tolerance
K Zmajkovicova, V Jesenberger, F Catalanotti… - Molecular cell, 2013 - cell.com
Summary The Raf/MEK/ERK and PI3K/Akt pathways are prominent effectors of oncogenic
Ras. These pathways negatively regulate each other, but the mechanism involved is …
Ras. These pathways negatively regulate each other, but the mechanism involved is …
Differential contribution of hypothalamic MAPK activity to anxiety-like behaviour in virgin and lactating rats
B Jurek, DA Slattery, R Maloumby, K Hillerer… - PloS one, 2012 - journals.plos.org
The c-Raf–MEK1/2–ERK1/2 mitogen-activated protein kinase (MAPK) intracellular signalling
cascade in neurons plays important roles in the control of a variety of behaviours, including …
cascade in neurons plays important roles in the control of a variety of behaviours, including …
3D microenvironment attenuates simulated microgravity-mediated changes in T cell transcriptome
Human space travel and exploration are of interest to both the industrial and scientific
community. However, there are many adverse effects of spaceflight on human physiology. In …
community. However, there are many adverse effects of spaceflight on human physiology. In …
WWOX phosphorylation, signaling, and role in neurodegeneration
CC Liu, PC Ho, IT Lee, YA Chen, CH Chu… - Frontiers in …, 2018 - frontiersin.org
Homozygous null mutation of tumor suppressor WWOX/Wwox gene leads to severe neural
diseases, metabolic disorders and early death in the newborns of humans, mice and rats …
diseases, metabolic disorders and early death in the newborns of humans, mice and rats …
Molecular functions of WWOX potentially involved in cancer development
K Taouis, K Driouch, R Lidereau, F Lallemand - Cells, 2021 - mdpi.com
The WW domain-containing oxidoreductase gene (WWOX) was cloned 21 years ago as a
putative tumor suppressor gene mapping to chromosomal fragile site FRA16D. The …
putative tumor suppressor gene mapping to chromosomal fragile site FRA16D. The …
[HTML][HTML] WW domain-containing oxidoreductase in neuronal injury and neurological diseases
HT Chang, CC Liu, ST Chen, YV Yap, NS Chang… - Oncotarget, 2014 - ncbi.nlm.nih.gov
The human and mouse WWOX/Wwox gene encodes a candidate tumor suppressor WW
domain-containing oxidoreductase protein. This gene is located on a common fragile site …
domain-containing oxidoreductase protein. This gene is located on a common fragile site …
[HTML][HTML] Trafficking protein particle complex 6A delta (TRAPPC6AΔ) is an extracellular plaque-forming protein in the brain
Tumor suppressor WWOX is involved in the progression of cancer and neurodegeneration.
Here, we examined whether protein aggregation occurs in the brain of nondemented …
Here, we examined whether protein aggregation occurs in the brain of nondemented …
The common fragile site FRA16D gene product WWOX: roles in tumor suppression and genomic stability
The fragile WWOX gene, encompassing the chromosomal fragile site FRA16D, is frequently
altered in human cancers. While vulnerable to DNA damage itself, recent evidence has …
altered in human cancers. While vulnerable to DNA damage itself, recent evidence has …