Design of experiments in the optimization of nanoparticle-based drug delivery systems

R Rampado, D Peer - Journal of Controlled Release, 2023 - Elsevier
Abstract Design of experiment (DoE) is a powerful statistical technique used for variable
screening and optimization. It is based on the simultaneous variation of multiple factors with …

Exploring the role of self-nanoemulsifying systems in drug delivery: challenges, issues, applications and recent advances

R Verma, V Mittal, P Pandey, S Bhatia… - Current Drug …, 2023 - ingentaconnect.com
Nanotechnology has attracted researchers around the globe owing to the small size and
targeting properties of the drug delivery vectors. The interest in self-nanoemulsifying drug …

Development of polymeric-based formulation as potential smart colonic drug delivery system

MF Bayan, SM Marji, MS Salem, MY Begum… - Polymers, 2022 - mdpi.com
Conventional oral formulations are mainly absorbed in the small intestine. This limits their
use in the treatment of some diseases associated with the colon, where the drug has to act …

Oral self-emulsifying nanoemulsion systems for enhancing dissolution, bioavailability and anticancer effects of camptothecin

ST Galatage, R Trivedi, DA Bhagwat - Journal of Drug Delivery Science …, 2022 - Elsevier
This research aimed to prepare a camptothecin (CPT) loaded self nano emulsifying drug
delivery system (SNEDDS) that would improve the oral therapeutic efficacy of CPT. 3 2 full …

Oral self-nanoemulsifying drug delivery systems for enhancing bioavailability and anticancer potential of fosfestrol: In vitro and In vivo characterization

ST Galatage, AS Manjappa, DA Bhagwat… - European Journal of …, 2023 - Elsevier
Purpose The objective of the current research work was to fabricate a fosfestrol (FST)-
loaded self-nanoemulsifying drug delivery system (SNEDDS) to escalate the oral solubility …

Improvement of the bioavailability of curcumin by a supersaturatable self nanoemulsifying drug delivery system with incorporation of a hydrophilic polymer: in vitro and …

X Chen, X Liang, G Zhao, Q Zeng… - Journal of Pharmacy …, 2021 - academic.oup.com
Objectives The current study was focused on preparing curcumin (CUR) supersaturated self-
nano-emulsion (PI-CUR-SNEDDS) using hydrophilic polymer and to study the influence of …

SEDDS basic design and recent formulation advancement: a concurrent review

KC Panigrahi, CN Patra, MEB Rao… - Pharmaceutical …, 2022 - ingentaconnect.com
In the present scenario, lipid-based novel drug delivery systems are the area of interest for
the formulation scientist in order to improve the bioavailability of poorly water-soluble drugs …

Investigation of in vivo bioavailability enhancement of iloperidone-loaded solid self-nanoemulsifying drug delivery systems: Formulation and optimization using Box …

ER Rani, GV Radha - Journal of Pharmaceutical Innovation, 2023 - Springer
Purpose The current research focuses on enhancement of in vitro dissolution and in vivo
bioavailability characteristics of iloperidone (IP) by formulation, optimization of L-SNEDDS …

[PDF][PDF] Drug release control and enhancement using carriers with different concentrations of Capmul® MCM C8

MF Bayan - Int. J. Appl. Pharm, 2021 - academia.edu
Objective: The main aim of this study was to design a drug carrier capable to control and
enhance the release of poorly water soluble drugs. Methods: Three polymeric formulations …

Development and Validation a UPLC-MS/MS Method for Quantification of Pentoxifylline in Beagle Plasma: Application for Pharmacokinetic Study of Food Effect

Y Xu, X Gao, Y Zhu, Q Zhang, H Qie… - Drug Design …, 2023 - Taylor & Francis
Purpose To develop an UPLC-MS/MS method for the quantitative analysis of pentoxifylline
in beagle dog plasma and apply it to a pharmacokinetic study of food effect. Methods …