Chemically fueled self‐assembly in biology and chemistry
Life is a non‐equilibrium state of matter maintained at the expense of energy. Nature uses
predominantly chemical energy stored in thermodynamically activated, but kinetically stable …
predominantly chemical energy stored in thermodynamically activated, but kinetically stable …
Protein language: post-translational modifications talking to each other
Post-translational modifications (PTMs) are at the heart of many cellular signaling events.
Apart from a single regulatory PTM, there are also PTMs that function in orchestrated …
Apart from a single regulatory PTM, there are also PTMs that function in orchestrated …
Proximity-inducing modalities: the past, present, and future
Living systems use proximity to regulate biochemical processes. Inspired by this
phenomenon, bifunctional modalities that induce proximity have been developed to redirect …
phenomenon, bifunctional modalities that induce proximity have been developed to redirect …
Modulation of phosphoprotein activity by phosphorylation targeting chimeras (PhosTACs)
Protein phosphorylation, which regulates many critical aspects of cell biology, is dynamically
governed by kinases and phosphatases. Many diseases are associated with dysregulated …
governed by kinases and phosphatases. Many diseases are associated with dysregulated …
Beyond proteolysis-targeting chimeric molecules: designing heterobifunctional molecules based on functional effectors
L Hua, Q Zhang, X Zhu, R Wang, Q You… - Journal of Medicinal …, 2022 - ACS Publications
In recent years, with the successful development of proteolysis-targeting chimeric molecules
(PROTACs), the potential of heterobifunctional molecules to contribute to reenvisioning drug …
(PROTACs), the potential of heterobifunctional molecules to contribute to reenvisioning drug …
Proteomics: a powerful tool to study plant responses to biotic stress
Y Liu, S Lu, K Liu, S Wang, L Huang, L Guo - Plant Methods, 2019 - Springer
In recent years, mass spectrometry-based proteomics has provided scientists with the
tremendous capability to study plants more precisely than previously possible. Currently …
tremendous capability to study plants more precisely than previously possible. Currently …
Phosphorus compounds of natural origin: Prebiotic, stereochemistry, application
OI Kolodiazhnyi - Symmetry, 2021 - mdpi.com
Organophosphorus compounds play a vital role as nucleic acids, nucleotide coenzymes,
metabolic intermediates and are involved in many biochemical processes. They are part of …
metabolic intermediates and are involved in many biochemical processes. They are part of …
Phosphopeptide enrichment for phosphoproteomic analysis-a tutorial and review of novel materials
Significant technical advancements in phosphopeptide enrichment have enabled the
identification of thousands of p-peptides (mono and multiply phosphorylated) in a single …
identification of thousands of p-peptides (mono and multiply phosphorylated) in a single …
Accelerating the field of epigenetic histone modification through mass spectrometry–based approaches
Histone post-translational modifications (PTMs) are one of the main mechanisms of
epigenetic regulation. Dysregulation of histone PTMs leads to many human diseases, such …
epigenetic regulation. Dysregulation of histone PTMs leads to many human diseases, such …
A panoramic view of the genomic landscape of the genus Streptomyces
M Nikolaidis, A Hesketh, N Frangou… - Microbial …, 2023 - microbiologyresearch.org
We delineate the evolutionary plasticity of the ecologically and biotechnologically important
genus Streptomyces, by analysing the genomes of 213 species. Streptomycetes genomes …
genus Streptomyces, by analysing the genomes of 213 species. Streptomycetes genomes …