The beta2‐adrenergic receptor – a re‐emerging target to combat obesity and induce leanness?

M Hostrup, J Onslev - The Journal of Physiology, 2022 - Wiley Online Library
Abstract Treatment of obesity with repurposed or novel drugs is an expanding research field.
One approach is to target beta2‐adrenergic receptors because they regulate the metabolism …

Factors influencing AMPK activation during cycling exercise: a pooled analysis and meta-regression

JA Rothschild, H Islam, DJ Bishop, AE Kilding… - Sports Medicine, 2022 - Springer
Background The 5ʹ adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a
cellular energy sensor that is activated by increases in the cellular AMP/adenosine …

Anabolic and lipolytic actions of beta2‐agonists in humans and antidoping challenges

M Hostrup, GA Jacobson, S Jessen… - Drug Testing and …, 2020 - Wiley Online Library
Inhaled beta2‐adrenoceptor agonists (beta2‐agonists) are among the most used
substances in competitive sports. The 2020 Prohibited List issued by the World Anti‐Doping …

Intramuscular lipid utilization during exercise: a systematic review, meta-analysis, and meta-regression

JR Stokie, G Abbott, KF Howlett… - Journal of Applied …, 2023 - journals.physiology.org
Intramuscular lipid (IMCL) utilization during exercise was controversial as numerous studies
did not observe a decline in IMCL content post-exercise when assessed in muscle biopsies …

β2‐Adrenergic stimulation enhances Ca2+ release and contractile properties of skeletal muscles, and counteracts exercise‐induced reductions in Na+–K+‐ATPase …

M Hostrup, A Kalsen, N Ørtenblad, C Juel… - The Journal of …, 2014 - Wiley Online Library
Key points From animal models, it is well established that β2‐adrenergic stimulation
increases contractile force, rates of Ca2+ release and uptake from the sarcoplasmic …

Chronic β2‐adrenoceptor agonist treatment alters muscle proteome and functional adaptations induced by high intensity training in young men

M Hostrup, J Onslev, GA Jacobson… - The Journal of …, 2018 - Wiley Online Library
Key points While several studies have investigated the effects of exercise training in human
skeletal muscle and the chronic effect of β2‐agonist treatment in rodent muscle, their effects …

Annual banned‐substance review: analytical approaches in human sports drug testing

M Thevis, T Kuuranne, H Geyer… - Drug testing and …, 2017 - Wiley Online Library
There has been an immense amount of visibility of doping issues on the international stage
over the past 12 months with the complexity of doping controls reiterated on various …

Mechanisms underlying enhancements in muscle force and power output during maximal cycle ergometer exercise induced by chronic β2-adrenergic stimulation in …

M Hostrup, A Kalsen, J Onslev… - Journal of Applied …, 2015 - journals.physiology.org
The study was a randomized placebo-controlled trial investigating mechanisms by which
chronic β2-adrenergic stimulation enhances muscle force and power output during maximal …

Inhaled beta2‐agonist, formoterol, enhances intense exercise performance, and sprint ability in elite cyclists

JS Jeppesen, S Jessen, M Thomassen… - … journal of medicine …, 2024 - Wiley Online Library
Purpose Many athletes use long‐acting beta2‐agonist formoterol in treatment of asthma.
However, studies in non‐athlete cohorts demonstrate that inhaled formoterol can enhance …

The World Anti-Doping Code: can you have asthma and still be an elite athlete?

K Fitch - Breathe, 2016 - Eur Respiratory Soc
Key points The World Anti-Doping Code (the Code) does place some restrictions on
prescribing inhaled β2-agonists, but these can be overcome without jeopardising the …