The use of living bacteria either as therapeutic agents or drug carriers has shown great
potential in treating a multitude of intractable diseases. However, cells are often fragile to …

Lactic acid bacteria (LAB) have a long history of safe exploitation by humans, being used for
centuries in food production and preservation and as probiotic agents to promote human …

Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease. Tumors are
poorly immunogenic and immunosuppressive, preventing T cell activation in the tumor …

We developed a novel surface display system based on the use of bacterial spores. A
protein of the Bacillus subtilis spore coat, CotB, was found to be located on the spore surface …

The use of live bacteria to induce an immune response to itself or to a carried vaccine
component is an attractive vaccine strategy. Advantages of live bacterial vaccines include …

Evidence is accumulating that lactobacilli influence the immune response in a strain-
dependent manner. This immunomodulatory capacity is important for the development of the …

Lactic acid bacteria (LAB), widely used in the food industry, are present in the intestine of
most animals, including humans. The potential use of these bacteria as live vehicles for the …

We report the use of CotC, a major component of the Bacillus subtilis spore coat, as a fusion
partner for the expression of two heterologous antigens on the spore coat. Recombinant …

The delivery of vaccines through the mucosal route is very practical, non-invasive and
efficacious for the induction of mucosal and systemic immune responses. Appropriately …

Lactobacillus plantarum NCIMB8826 was selected as a bacterial carrier for the development
of live mucosal vaccines. This strain was reported to display interesting pharmaco-kinetic …