Structure, function, and pharmacology of glutamate receptor ion channels

KB Hansen, LP Wollmuth, D Bowie, H Furukawa… - Pharmacological …, 2021 - Elsevier
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

The AMPA receptor code of synaptic plasticity

GH Diering, RL Huganir - Neuron, 2018 - cell.com
Changes in the properties and postsynaptic abundance of AMPA-type glutamate receptors
(AMPARs) are major mechanisms underlying various forms of synaptic plasticity, including …

Structural and functional architecture of AMPA-type glutamate receptors and their auxiliary proteins

IH Greger, JF Watson, SG Cull-Candy - Neuron, 2017 - cell.com
AMPA receptors (AMPARs) are tetrameric ion channels that together with other ionotropic
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …

[HTML][HTML] AMPA receptor trafficking and LTP: Carboxy-termini, amino-termini and TARPs

J Díaz-Alonso, RA Nicoll - Neuropharmacology, 2021 - Elsevier
AMPA receptors (AMPARs) are fundamental elements in excitatory synaptic transmission
and synaptic plasticity in the CNS. Long term potentiation (LTP), a form of synaptic plasticity …

Subsynaptic positioning of AMPARs by LRRTM2 controls synaptic strength

AM Ramsey, AH Tang, TA LeGates, XZ Gou… - Science …, 2021 - science.org
Recent evidence suggests that nano-organization of proteins within synapses may control
the strength of communication between neurons in the brain. The unique subsynaptic …

AMPA receptor structure and auxiliary subunits

A Kamalova, T Nakagawa - The Journal of physiology, 2021 - Wiley Online Library
Fast excitatory synaptic transmission in the mammalian brain is largely mediated by AMPA‐
type ionotropic glutamate receptors (AMPARs), which are activated by the neurotransmitter …

[HTML][HTML] Glutamate-induced AMPA receptor desensitization increases their mobility and modulates short-term plasticity through unbinding from Stargazin

A Constals, AC Penn, B Compans, E Toulme… - Neuron, 2015 - cell.com
Short-term plasticity of AMPAR currents during high-frequency stimulation depends not only
on presynaptic transmitter release and postsynaptic AMPAR recovery from desensitization …

Transsynaptic modulation of kainate receptor functions by C1q-like proteins

K Matsuda, T Budisantoso, N Mitakidis, Y Sugaya… - Neuron, 2016 - cell.com
Postsynaptic kainate-type glutamate receptors (KARs) regulate synaptic network activity
through their slow channel kinetics, most prominently at mossy fiber (MF)-CA3 synapses in …

Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy

EC Twomey, MV Yelshanskaya, RA Grassucci, J Frank… - Science, 2016 - science.org
AMPA-subtype ionotropic glutamate receptors (AMPARs) mediate fast excitatory
neurotransmission and contribute to high cognitive processes such as learning and memory …

Structure and organization of heteromeric AMPA-type glutamate receptors

B Herguedas, J García-Nafría, O Cais… - Science, 2016 - science.org
INTRODUCTION Ionotropic glutamate receptors (iGluRs) are cation channels that mediate
signal transmission by depolarizing the postsynaptic membrane in response to L-glutamate …