Testing at scale during the COVID-19 pandemic

TR Mercer, M Salit - Nature Reviews Genetics, 2021 - nature.com
Assembly and publication of the severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) genome in January 2020 enabled the immediate development of tests to detect the …

Performance of saliva, oropharyngeal swabs, and nasal swabs for SARS-CoV-2 molecular detection: a systematic review and meta-analysis

RA Lee, JC Herigon, A Benedetti… - Journal of clinical …, 2021 - Am Soc Microbiol
Nasopharyngeal (NP) swabs are considered the highest-yield sample for diagnostic testing
for respiratory viruses, including SARS-CoV-2. The need to increase capacity for SARS-CoV …

[HTML][HTML] Tuberculosis and COVID-19 interaction: a review of biological, clinical and public health effects

D Visca, CWM Ong, S Tiberi, R Centis, L D'ambrosio… - Pulmonology, 2021 - Elsevier
Evidence is accumulating on the interaction between tuberculosis (TB) and COVID-19. The
aim of the present review is to report the available evidence on the interaction between …

The sensitivity and costs of testing for SARS-CoV-2 infection with saliva versus nasopharyngeal swabs: a systematic review and meta-analysis

ML Bastos, S Perlman-Arrow, D Menzies… - Annals of internal …, 2021 - acpjournals.org
Background: Nasopharyngeal swabs are the primary sampling method used for detection of
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but they require a trained …

COVID-19 point-of-care diagnostics: present and future

E Valera, A Jankelow, J Lim, V Kindratenko… - ACS …, 2021 - ACS Publications
Point-of-care (POC) detection technologies that enable decentralized, rapid, sensitive, low-
cost diagnostics of COVID-19 infection are urgently needed around the world. With many …

Just 2% of SARS-CoV-2− positive individuals carry 90% of the virus circulating in communities

Q Yang, TK Saldi, PK Gonzales… - Proceedings of the …, 2021 - National Acad Sciences
We analyze data from the fall 2020 pandemic response efforts at the University of Colorado
Boulder, where more than 72,500 saliva samples were tested for severe acute respiratory …

Amplification-free RNA detection with CRISPR–Cas13

H Shinoda, Y Taguchi, R Nakagawa, A Makino… - Communications …, 2021 - nature.com
CRISPR-based nucleic-acid detection is an emerging technology for molecular diagnostics.
However, these methods generally require several hours and could cause amplification …

An engineered CRISPR-Cas12a variant and DNA-RNA hybrid guides enable robust and rapid COVID-19 testing

KH Ooi, MM Liu, JWD Tay, SY Teo… - Nature …, 2021 - nature.com
Extensive testing is essential to break the transmission of SARS-CoV-2, which causes the
ongoing COVID-19 pandemic. Here, we present a CRISPR-based diagnostic assay that is …

LAMP diagnostics at the point-of-care: emerging trends and perspectives for the developer community

TJ Moehling, G Choi, LC Dugan, M Salit… - Expert Review of …, 2021 - Taylor & Francis
Introduction: Over the past decade, loop-mediated isothermal amplification (LAMP)
technology has played an important role in molecular diagnostics. Amongst numerous …

A rapid, accurate, scalable, and portable testing system for COVID-19 diagnosis

G Xun, ST Lane, VA Petrov, BE Pepa, H Zhao - Nature communications, 2021 - nature.com
The need for rapid, accurate, and scalable testing systems for COVID-19 diagnosis is clear
and urgent. Here, we report a rapid S calable and Po rtable T esting (SPOT) system …