Lung disease is the major cause of morbidity and mortality in patients with cystic fibrosis
(CF). Although CF lung disease is primarily an infectious disorder, the associated …

Inflammation plays a critical role in cystic fibrosis (CF) lung pathology and disease
progression making it an active area of research and important therapeutic target. In this …

Dysregulated inflammasome activation contributes to respiratory infections and pathologic
airway inflammation. Through basic and translational approaches involving murine models …

IDO1 (indoleamine 2, 3-dioxygenase 1) is a member of a unique class of mammalian haem
dioxygenases that catalyse the oxidative catabolism of the least-abundant essential amino …

The aromatic amino acid L-tryptophan (Trp) is essentially metabolized along the host and
microbial pathways. While much is known about the role played by downstream metabolites …

Since IL-37 transgenic mice possesses broad anti-inflammatory properties, we assessed
whether recombinant IL-37 affects inflammation in a murine model of invasive pulmonary …

As a result of a long evolutionary history, serotonin plays a variety of physiological roles,
including neurological, cardiovascular, gastrointestinal, and endocrine functions. While …

Abstract T helper 9 (Th9) cells contribute to lung inflammation and allergy as sources of
interleukin-9 (IL-9). However, the mechanisms by which IL-9/Th9 mediate immunopathology …

Background Biofilm is a community of bacteria embedded in an extracellular matrix, which
can colonize different human cells and tissues and subvert the host immune reactions by …

Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis
transmembrane conductance regulator (CFTR) that compromise its chloride channel activity …