Animal models are extensively used in all aspects of biomedical research, with substantial
contributions to our understanding of diseases, the development of pharmaceuticals, and …

Recent advancements in disease modeling for myocardial infarction (MI) and coronary
artery disease (CAD) have significantly enhanced our understanding of cardiovascular …

Microalgae have emerged as promising photosynthetic microorganisms for biofabricating
advanced tissue constructs, with improved oxygenation and reduced reactive oxygen …

The use of animal models is crucial for advancing translational research by identifying and
validating effective treatment targets and strategies for clinical application in human disease …

Coronary heart disease is a major global health threat, with acute myocardial ischemia–
reperfusion injury (IRI) being a major contributor to myocardial damage following an …

Current therapeutic drug exploring targeting at myocardial ischemia/reperfusion (I/R) injury
is limited due to the lack of humanized cardiac models that resemble myocardial damage …

Sustained adrenergic overload in the heart causes maladaptive cardiac remodelling, which
involves oxidative stress. Boldine (BOL) has antioxidant activity and represents a novel …

Objective To establish a preclinical large-animal model of Deinagkistrodon acutus snakebite
envenomation and evaluate its feasibility. Methods The venom of D. acutus (0 mg/kg, 1 …

Animal models are integral to the study of fundamental biological processes and the etiology
of human diseases. Small animal models, especially those involving mice, have yielded …

The molecular etiologies of many prevalent diseases stem from genetic variations that arise
during evolution and natural selection, as well as from environmental effects. The study of …