Trends in small molecule drug properties: A developability molecule assessment perspective
Developability molecule assessment is a key interfacial capability across the
biopharmaceutical industry, screening and staging molecules discovered by medicinal …
biopharmaceutical industry, screening and staging molecules discovered by medicinal …
Plasma protein-mediated uptake and contradictions to the free drug hypothesis: a critical review
JA Schulz, DM Stresser, JC Kalvass - Drug metabolism reviews, 2023 - Taylor & Francis
According to the free drug hypothesis (FDH), only free, unbound drug is available to interact
with biological targets. This hypothesis is the fundamental principle that continues to explain …
with biological targets. This hypothesis is the fundamental principle that continues to explain …
InVitro-InVivo Extrapolation and Scaling Factors for Clearance of Human and Preclinical Species with Liver Microsomes and Hepatocytes
D Tess, GC Chang, C Keefer, A Carlo, R Jones, L Di - The AAPS journal, 2023 - Springer
In vitro-in vivo extrapolation ((IVIVE) and empirical scaling factors (SF) of human intrinsic
clearance (CLint) were developed using one of the largest dataset of 455 compounds with …
clearance (CLint) were developed using one of the largest dataset of 455 compounds with …
[HTML][HTML] CNS delivery of targeted protein degraders
Heterobifunctional small molecule degraders are a subset of targeted protein degraders
(TPDs), consisting of two ligands joined by a linker to induce proteasomal degradation of a …
(TPDs), consisting of two ligands joined by a linker to induce proteasomal degradation of a …
Drug Design and Success of Prospective Mouse In Vitro–In Vivo Extrapolation (IVIVE) for Predictions of Plasma Clearance (CLp) from Hepatocyte Intrinsic Clearance …
Hepatocyte intrinsic clearance (CLint) and methods of in vitro–in vivo extrapolation (IVIVE)
are often used to predict plasma clearance (CLp) in drug discovery. While the prediction …
are often used to predict plasma clearance (CLp) in drug discovery. While the prediction …
[PDF][PDF] Molecular interaction and inhibitory activity of Dandelion's compounds on nucleoprotein: A therapeutic intervention in Lassa fever
Lassa fever (LF) is an acute and sometimes fatal viral hemorrhagic fever caused by the
Lassa virus (LASV). It is a major public health challenge and endemic exclusively in West …
Lassa virus (LASV). It is a major public health challenge and endemic exclusively in West …