Pericytes, the mural cells of blood microvessels, have recently come into focus as regulators
of vascular morphogenesis and function during development, cardiovascular homeostasis …

Notch signaling induced by canonical Notch ligands is critical for normal embryonic
development and tissue homeostasis through the regulation of a variety of cell fate decisions …

Abstract Purpose: The Notch pathway plays an important role in both stem cell biology and
cancer. Dysregulation of Notch signaling has been reported in several human tumor types …

The Notch signaling pathway regulates a diverse array of cell types and cellular processes
and is tightly regulated by ligand binding. Both canonical and noncanonical Notch ligands …

The Notch pathway is increasingly attracting attention as a source of therapeutic targets for
cancer. Ligand-induced Notch signaling has been implicated in various aspects of cancer …

Endothelial cells and mural cells (smooth muscle cells, pericytes, or fibroblasts) are known
to communicate with one another. Their interactions not only serve to support fully functional …

Angiogenesis is required in cancer, including gynecological cancers, for the growth of
primary tumors and secondary metastases. Development of anti-angiogenesis therapy in …

Multiple molecular, cellular, micro-environmental and systemic causes of anticancer drug
resistance have been identified during the last 25 years. At the same time, genome-wide …

Background Pericytes are multipotent cells present in every vascularized tissue in the body.
Despite the fact that they are well-known for more than a century, pericytes are still …

Angiogenesis, the formation of new blood vessels from existing vasculature, plays an
essential role in tumour growth, invasion and metastasis. Vascular endothelial growth factor …