Intrinsically disordered proteins in cellular signalling and regulation

PE Wright, HJ Dyson - Nature reviews Molecular cell biology, 2015 - nature.com
Intrinsically disordered proteins (IDPs) are important components of the cellular signalling
machinery, allowing the same polypeptide to undertake different interactions with different …

Interaction modules that impart specificity to disordered protein

K Cermakova, HC Hodges - Trends in biochemical sciences, 2023 - cell.com
Intrinsically disordered regions (IDRs) are especially enriched among proteins that regulate
chromatin and transcription. As a result, mechanisms that influence specificity of IDR-driven …

Role of intrinsic protein disorder in the function and interactions of the transcriptional coactivators CREB-binding protein (CBP) and p300

HJ Dyson, PE Wright - Journal of Biological Chemistry, 2016 - ASBMB
The transcriptional coactivators CREB-binding protein (CBP) and p300 undergo a
particularly rich set of interactions with disordered and partly ordered partners, as a part of …

How viruses hijack cell regulation

NE Davey, G Travé, TJ Gibson - Trends in biochemical sciences, 2011 - cell.com
Viruses, as obligate intracellular parasites, are the pathogens that have the most intimate
relationship with their host, and as such, their genomes have been shaped directly by …

Modulation of allostery by protein intrinsic disorder

ACM Ferreon, JC Ferreon, PE Wright, AA Deniz - Nature, 2013 - nature.com
Allostery is an intrinsic property of many globular proteins and enzymes that is
indispensable for cellular regulatory and feedback mechanisms. Recent theoretical and …

Emerging antiviral therapeutics for human adenovirus infection: Recent developments and novel strategies

MJ Dodge, KM MacNeil, TM Tessier, JB Weinberg… - Antiviral research, 2021 - Elsevier
Human adenoviruses (HAdV) are ubiquitous human pathogens that cause a significant
burden of respiratory, ocular, and gastrointestinal illnesses. Although HAdV infections are …

Viral and cellular interactions during adenovirus DNA replication

M Charman, C Herrmann, MD Weitzman - FEBS letters, 2019 - Wiley Online Library
Adenoviruses represent ubiquitous and clinically significant human pathogens, gene‐
delivery vectors, and oncolytic agents. The study of adenovirus‐infected cells has long been …

FOXM1 (Forkhead box M1) in tumorigenesis: overexpression in human cancer, implication in tumorigenesis, oncogenic functions, tumor-suppressive properties, and …

I Wierstra - Advances in cancer research, 2013 - Elsevier
Abstract FOXM1 (Forkhead box M1) is a typical proliferation-associated transcription factor
and is also intimately involved in tumorigenesis. FOXM1 stimulates cell proliferation and cell …

Metabolic reprogramming of the host cell by human adenovirus infection

MA Prusinkiewicz, JS Mymryk - Viruses, 2019 - mdpi.com
Viruses are obligate intracellular parasites that alter many cellular processes to create an
environment optimal for viral replication. Reprogramming of cellular metabolism is an …

Novel viral splicing events and open reading frames revealed by long-read direct RNA sequencing of adenovirus transcripts

AM Price, RT Steinbock, R Lauman, M Charman… - PLoS …, 2022 - journals.plos.org
Adenovirus is a common human pathogen that relies on host cell processes for transcription
and processing of viral RNA and protein production. Although adenoviral promoters, splice …