Mitogen-activated protein (MAP) kinases are a central component in signaling networks in a
multitude of mammalian cell types. This review covers recent advances on specific functions …

There are several candidate signalling pathways that mediate the response of the central
nervous system (CNS) cells to environmental toxins. However, much is still to be learned on …

Background & Aims Tumor necrosis factor receptor-associated factor 1 (TRAF1) is an
important adapter protein that is largely implicated in molecular events regulating …

Background Agomelatine has been shown to be effective in the treatment of depression, but
the molecular mechanisms underlying its antidepressant effects have yet to be elucidated …

Abstract α-synuclein abnormal accumulation and mitochondria dysfunction are involved in
the pathogenesis of Parkinson's disease. Selective autophagy of mitochondria (mitophagy) …

Nonalcoholic fatty liver disease (NAFLD), ranging from nonalcoholic fatty liver to
nonalcoholic steatohepatitis (NASH), is the leading cause of chronic liver diseases. Until …

Significance: The thioredoxin system comprises thioredoxin (Trx), thioredoxin reductase
(TrxR), and nicotinamide adenine dinucleotide phosphate, besides an endogenous Trx …

Pyrethroids are a class of synthetic insecticides that are used widely in and around
households to control the pest. Concerns about exposure to this group of pesticides are now …

In this study, total flavonoids and total triterpenoid acid were extracted with ethyl acetate from
Hedyotis diffusa Willd, and hepatoprotective activities of them and five compounds from total …

We recently found that tumor necrosis factor-α (TNF-α) may be involved in neuronal cell
death induced by methylmercury in the mouse brain. Here, we examined the cells involved …