[HTML][HTML] Targeting oncomiRNAs and mimicking tumor suppressor miRNAs: Νew trends in the development of miRNA therapeutic strategies in oncology
R Gambari, E Brognara… - … journal of oncology, 2016 - spandidos-publications.com
MicroRNA (miRNA or miR) therapeutics in cancer are based on targeting or mimicking
miRNAs involved in cancer onset, progression, angiogenesis, epithelial-mesenchymal …
miRNAs involved in cancer onset, progression, angiogenesis, epithelial-mesenchymal …
MicroRNA-125 in immunity and cancer
JK Wang, Z Wang, G Li - Cancer letters, 2019 - Elsevier
MicroRNAs (miRNAs) are small non-coding RNAs that play a wide variety of critical roles in
different biological processes by post-transcriptionally regulating gene expression. They …
different biological processes by post-transcriptionally regulating gene expression. They …
Essential functions of miR‐125b in cancer
MicroRNAs (miRNAs) are small and highly conserved non‐coding RNAs that silence target
mRNAs, and compelling evidence suggests that they play an essential role in the …
mRNAs, and compelling evidence suggests that they play an essential role in the …
SAFB2 enables the processing of suboptimal stem-loop structures in clustered primary miRNA transcripts
K Hutter, M Lohmüller, A Jukic, F Eichin, S Avci, V Labi… - Molecular cell, 2020 - cell.com
Many microRNAs (miRNAs) are generated from primary transcripts containing multiple
clustered stem-loop structures that are thought to be recognized and cleaved by the …
clustered stem-loop structures that are thought to be recognized and cleaved by the …
[HTML][HTML] Combination of bulk RNA sequencing and scRNA sequencing uncover the molecular characteristics of MAPK signaling in kidney renal clear cell carcinoma
X Li, H Guan, C Ma, Y Dai, J Su, X Chen… - Aging (Albany …, 2024 - ncbi.nlm.nih.gov
The MAPK signaling pathway significantly impacts cancer progression and resistance;
however, its functions remain incompletely assessed across various cancers, particularly in …
however, its functions remain incompletely assessed across various cancers, particularly in …
Identification of immune-related genes in diagnosing atherosclerosis with rheumatoid arthritis through bioinformatics analysis and machine learning
F Liu, Y Huang, F Liu, H Wang - Frontiers in Immunology, 2023 - frontiersin.org
Background Increasing evidence has proven that rheumatoid arthritis (RA) can aggravate
atherosclerosis (AS), and we aimed to explore potential diagnostic genes for patients with …
atherosclerosis (AS), and we aimed to explore potential diagnostic genes for patients with …
Optimization of Cas12a for multiplexed genome-scale transcriptional activation
Cas12a CRISPR technology, unlike Cas9, allows for facile multiplexing of guide RNAs from
a single transcript, simplifying combinatorial perturbations. While Cas12a has been …
a single transcript, simplifying combinatorial perturbations. While Cas12a has been …
The BTG2-PRMT1 module limits pre-B cell expansion by regulating the CDK4-Cyclin-D3 complex
E Dolezal, S Infantino, F Drepper, T Börsig… - Nature …, 2017 - nature.com
Developing pre-B cells in the bone marrow alternate between proliferation and
differentiation phases. We found that protein arginine methyl transferase 1 (PRMT1) and B …
differentiation phases. We found that protein arginine methyl transferase 1 (PRMT1) and B …
Epigenetic silencing of miR-125b is required for normal B-cell development
Deregulation of several microRNAs (miRs) can influence critical developmental checkpoints
during hematopoiesis as well as cell functions, eventually leading to the development of …
during hematopoiesis as well as cell functions, eventually leading to the development of …
[HTML][HTML] MicroRNAs: new players in cataract
Cataract is the most common cause of blindness worldwide. Multiple factors such as aging,
eye injury, diabetes mellitus, ultraviolet exposure, drug use and other ocular diseases are …
eye injury, diabetes mellitus, ultraviolet exposure, drug use and other ocular diseases are …