Richter transformation (RT) is the development of aggressive lymphoma–most frequently
diffuse large B-cell lymphoma (DLBCL) and rarely Hodgkin lymphoma (HL)–arising on the …

Recent approvals of several oral targeted agents have revolutionized chronic lymphocytic
leukemia (CLL) therapy. However, CLL patients continue to progress; particularly, 4% to …

Background Richter transformation usually presents as an aggressive diffuse large B-cell
lymphoma, occurs in up to 10% of patients with chronic lymphocytic leukaemia, has no …

Richter syndrome represents the evolution of chronic lymphocytic leukemia into an
aggressive tumor, most commonly diffuse large B-cell lymphoma. The lack of in vitro and in …

Abstract Entospletinib (GS-9973), an oral, selective inhibitor of spleen tyrosine kinase (SYK),
was evaluated as monotherapy in this multicenter, phase 2 study (NCT01799889) of 49 …

The management of chronic lymphocytic leukemia (CLL) has undergone unprecedented
changes over the last decade. Modern targeted therapies are incorporated into clinical …

Simple Summary Richter transformation is a significant and devastating complication of
chronic lymphocytic leukemia. While its pathogenesis has been well-studied in terms of …

Introduction Chronic lymphocytic leukemia (CLL) is an indolent, low-grade B-cell
lymphoproliferative disorder, which may evolve into aggressive lymphoma, a phenomenon …

The increased use of several effective novel targeted therapy agents has revolutionized
therapy for patients with chronic lymphocytic leukemia (CLL). Disease progression in …

Richter's transformation (RT) refers to the development of an aggressive lymphoma in
patients with chronic lymphocytic leukemia (CLL). Approximately, 2–10% of patients with …