Validation of the γH2AX biomarker for genotoxicity assessment: a review
B Kopp, L Khoury, M Audebert - Archives of toxicology, 2019 - Springer
The H2AX histone protein is rapidly phosphorylated at the serine-139 position (γH2AX) in
response to a broad range of DNA lesions. γH2AX induction is one of the earliest events in …
response to a broad range of DNA lesions. γH2AX induction is one of the earliest events in …
Recent advances in γH2AX biomarker-based genotoxicity assays: A marker of DNA damage and repair
N Rahmanian, M Shokrzadeh, M Eskandani - DNA repair, 2021 - Elsevier
The phosphorylation of histone variant H2AX and formation of γH2AX is a primary response
to the DNA double-strand breaks (DSBs). Detection of γH2AX is a robust and sensitive tool …
to the DNA double-strand breaks (DSBs). Detection of γH2AX is a robust and sensitive tool …
[HTML][HTML] In vitro genotoxicity testing–Can the performance be enhanced?
R Corvi, F Madia - Food and Chemical Toxicology, 2017 - Elsevier
The assessment of genotoxicity represents an essential component of the safety assessment
of all types of substances. Several in vitro tests are available at different stages of …
of all types of substances. Several in vitro tests are available at different stages of …
Toxicological and pharmacokinetic properties of sucralose-6-acetate and its parent sucralose: in vitro screening assays
The purpose of this study was to determine the toxicological and pharmacokinetic properties
of sucralose-6-acetate, a structural analog of the artificial sweetener sucralose. Sucralose-6 …
of sucralose-6-acetate, a structural analog of the artificial sweetener sucralose. Sucralose-6 …
Guidance on aneugenicity assessment
EFSA Scientific Committee (SC), SJ More… - EFSA …, 2021 - Wiley Online Library
Abstract The EFSA Scientific Committee was asked to provide guidance on the most
appropriate in vivo tests to follow up on positive in vitro results for aneugenicity, and on the …
appropriate in vivo tests to follow up on positive in vitro results for aneugenicity, and on the …
[HTML][HTML] Exploring the safety of cannabidiol (CBD): A comprehensive in vitro evaluation of the genotoxic and mutagenic potential of a CBD isolate and extract from …
Cannabidiol (CBD), a naturally occurring cyclic terpenoid found in Cannabis sativa L., is
renowned for its diverse pharmacological benefits. Marketed as a remedy for various health …
renowned for its diverse pharmacological benefits. Marketed as a remedy for various health …
AOP report: Development of an adverse outcome pathway for deposition of energy leading to cataracts
E Carrothers, M Appleby, V Lai… - Environmental and …, 2024 - Wiley Online Library
Cataracts are one of the leading causes of blindness, with an estimated 95 million people
affected worldwide. A hallmark of cataract development is lens opacification, typically …
affected worldwide. A hallmark of cataract development is lens opacification, typically …
Investigation of cannabidiol-induced cytotoxicity in human hepatic cells
Cannabidiol (CBD) is one of the primary cannabinoids present in extracts of the plant
Cannabis sativa L. A CBD-based drug, Epidiolex, has been approved by the US FDA for the …
Cannabis sativa L. A CBD-based drug, Epidiolex, has been approved by the US FDA for the …
Application of a new approach methodology (NAM)-based strategy for genotoxicity assessment of data-poor compounds
The conventional battery for genotoxicity testing is not well suited to assessing the large
number of chemicals needing evaluation. Traditional in vitro tests lack throughput, provide …
number of chemicals needing evaluation. Traditional in vitro tests lack throughput, provide …