Reactive oxygen and nitrogen species (RONS) are generated through various endogenous
and exogenous processes; however, they are neutralized by enzymatic and non-enzymatic …

The aging process worsens the human body functions at multiple levels, thus causing its
gradual decrease to resist stress, damage, and disease. Besides changes in gene …

Mitochondrial dysfunction is a hallmark of multiple metabolic complications. Physical activity
is known to increase mitochondrial content in skeletal muscle, counteracting age-related …

SARS-CoV-2 causes a severe pneumonia (COVID-19) that affects essentially elderly
people. In COVID-19, macrophage infiltration into the lung causes a rapid and intense …

Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic lung disease of unknown etiology.
With a gradually increasing worldwide prevalence and a mortality rate exceeding that of …

Growing evidence suggests chronic low-grade inflammation (LGI) as a possible mechanism
underlying the aging process. Some biological and pharmaceutical compounds may reduce …

Coenzyme Q (CoQ) is a unique electron carrier in the mitochondrial respiratory chain, which
is synthesized on-site by a nuclear encoded multiprotein complex. CoQ receives electrons …

The stress-responsive mitochondrial sirtuin SIRT4 controls cellular energy metabolism in a
NAD+-dependent manner and is implicated in cellular senescence and aging. Here we …

A large amount of the longevity-modulating genes discovered during the last two decades
are highly conserved during evolution from yeast and invertebrates to mammals. Many …

Skeletal muscles require the proper production and distribution of energy to sustain their
work. To ensure this requirement is met, mitochondria form large networks within skeletal …