Acute lymphoblastic leukemia (ALL) is a hematological malignancy characterized by the
malignant clonal expansion of lymphoid hematopoietic precursors. It is regulated by various …

Ctip2/Bcl11b is a zinc finger transcription factor with dual action (repression/activation) that
couples epigenetic regulation to gene transcription during the development of various …

Blood flow and vascular shear stress patterns play a significant role in inducing and
modulating physiological responses of endothelial cells (ECs). Pulsatile shear (PS) is …

Leukemias with ambiguous lineage comprise several loosely defined entities, often without
a clear mechanistic basis. Here, we extensively profile the epigenome and transcriptome of …

Traditional treatments of small-cell lung cancer (SCLC) with cisplatin, a standard-of-care
therapy, spare the tumor-initiating cells (TIC) that mediate drug resistance. Here we report a …

Oxidative stress-induced follicular granulosa cell (GC) apoptosis plays an essential role in
abnormal follicular atresia, which may trigger ovarian dysfunction. To investigate the role of …

DNA methyltransferase 3A (DNMT3A) is an enzyme involved in DNA methylation that is
frequently mutated in human hematologic malignancies. We have previously shown that …

Ferroptosis is a recently-defined tumor suppression mechanism, but the sensitivity of many
tumorigenic cells to ferroptosis is limited by their deficient expression of acyl-CoA synthetase …

Acute myeloid leukemia (AML) is characterized by increased proliferation and blocked
differentiation of hematopoietic progenitors mediated, in part, by altered myeloid …

Chimeric antigen receptor (CAR) T cells have been successfully used in the therapy of B cell
leukemia and lymphoma, but still have many challenges in their use for treating T cell …