Discovered more than 30 years ago, the angiotensin AT 2 receptor (AT 2 R) has evolved
from a binding site with unknown function to a firmly established major effector within the …

The renin-angiotensin system is of vital significance not only in the maintenance of blood
pressure but also because of its role in the pathophysiology of different organ systems in the …

Angiotensin II (AngII), as an octapeptide hormone normally ionized at physiological pH,
cannot cross cell membranes and thus, relies on, two (mainly) G protein-coupled receptor …

Pulmonary fibrosis is a devastating lung disease with multifactorial etiology characterized by
alveolar injury, fibroblast proliferation and excessive deposition of extracellular matrix …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that is responsible for
the global corona virus disease 2019 (COVID-19) pandemic enters host cells via a …

Angiotensin II (AngII) uses two distinct G protein-coupled receptor (GPCR) types, AT 1 R and
AT 2 R, to exert a plethora of physiologic effects in the body and to significantly affect …

The angiotensin AT2 receptor (AT 2 R), an important member of the “protective arm” of the
renin-angiotensin system (RAS), has been recently defined as a therapeutic target in …

Despite the progressive improvements in diagnosis and therapy during the first 20 years of
this century, the morbidity and mortality of patients with heart failure (HF) remain high …

Abstract Angiotensin-(1–9)[Ang-(1–9)] is a peptide of the non-canonical renin-angiotensin
system (RAS) synthesized from angiotensin I by the monopeptidase angiotensin-converting …

Cardiorenal syndrome (CRS), a clinical syndrome involving multiple pathological
mechanisms, exhibits high morbidity and mortality. According to the primary activity of the …