Diverse macrophage populations mediate acute lung inflammation and resolution

NR Aggarwal, LS King… - American Journal of …, 2014 - journals.physiology.org
Acute respiratory distress syndrome (ARDS) is a devastating disease with distinct
pathological stages. Fundamental to ARDS is the acute onset of lung inflammation as a part …

Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding

KN Iskander, MF Osuchowski… - Physiological …, 2013 - journals.physiology.org
Sepsis represents the host's systemic inflammatory response to a severe infection. It causes
substantial human morbidity resulting in hundreds of thousands of deaths each year …

Temporal dynamics of cardiac immune cell accumulation following acute myocardial infarction

X Yan, A Anzai, Y Katsumata, T Matsuhashi… - Journal of molecular and …, 2013 - Elsevier
Acute myocardial infarction (MI) causes sterile inflammation, which is characterized by
recruitment and activation of innate and adaptive immune system cells. Here we delineate …

The pathogenesis of sepsis

DJ Stearns-Kurosawa, MF Osuchowski… - Annual review of …, 2011 - annualreviews.org
Sepsis is a serious clinical condition that represents a patient's response to a severe
infection and has a very high mortality rate. Normal immune and physiologic responses …

Function and inhibition of P38 MAP kinase signaling: Targeting multiple inflammation diseases

J Wang, Y Liu, Y Guo, C Liu, Y Yang, X Fan… - Biochemical …, 2024 - Elsevier
Inflammation is a natural host defense mechanism that protects the body from pathogenic
microorganisms. A growing body of research suggests that inflammation is a key factor in …

THP-1 and human peripheral blood mononuclear cell-derived macrophages differ in their capacity to polarize in vitro

H Shiratori, C Feinweber, S Luckhardt, B Linke… - Molecular …, 2017 - Elsevier
Macrophages (Mφ) undergo activation to pro-inflammatory (M1) or anti-inflammatory (M2)
phenotypes in response to pathophysiologic stimuli and dysregulation of the M1-M2 balance …

A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis

JS Boomer, J Shuherk-Shaffer, RS Hotchkiss… - Critical care, 2012 - Springer
Introduction Severe sepsis is characterized by an initial hyper-inflammatory response that
may progress to an immune-suppressed state associated with increased susceptibility to …

Development of exhausted memory monocytes and underlying mechanisms

K Pradhan, Z Yi, S Geng, L Li - Frontiers in Immunology, 2021 - frontiersin.org
Pathogenic inflammation and immuno-suppression are cardinal features of exhausted
monocytes increasingly recognized in septic patients and murine models of sepsis …

Remotely guided immunobots engaged in anti‐tumorigenic phenotypes for targeted cancer immunotherapy

NO Dogan, H Ceylan, E Suadiye, D Sheehan, A Aydin… - Small, 2022 - Wiley Online Library
Building medical microrobots from the body's own cells may circumvent the biocompatibility
concern and hence presents more potential in clinical applications to improve the possibility …

Functional evidence of pulmonary extracellular vesicles in infectious and noninfectious lung inflammation

H Lee, D Zhang, DL Laskin, Y Jin - The Journal of Immunology, 2018 - journals.aai.org
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a highly complex
process that can be triggered by both noninfectious (sterile) and infectious stimuli …