Motor neuron disease can be viewed as an umbrella term describing a heterogeneous
group of conditions, all of which are relentlessly progressive and ultimately fatal. The …

The availability of disease modifying therapies for spinal muscular atrophy (SMA) has
created an urgent need to identify clinically meaningful biomarkers. Biomarkers present a …

Introduction: Numerous methods for motor unit number estimation (MUNE) have been
developed. The objective of this article is to summarize and compare the major methods and …

Estimation of the number of motor units (MUNE) in specific muscles is important to monitor
outcome in progressive neurogenic disorders, with potential application in clinical trials …

Biomarkers have become the focus of intense research in the field of amyotrophic lateral
sclerosis (ALS), with the hope that they might aid therapy development efforts …

Disease heterogeneity in amyotrophic lateral sclerosis poses a substantial challenge in drug
development. Categorization based on clinical features alone can help us predict the …

Background Motor Unit Number Index (MUNIX) is a novel neurophysiological measure that
provides an index of the number of functional lower motor neurons in a given muscle. So far …

Objective To examine inter-and intra-rater reproducibility and sensitivity to motor unit loss of
a novel motor unit number estimation (MUNE) method, MScanFit MUNE (MScan), compared …

Objective To assess the repeatability and suitability for multicentre studies of MScanFit motor
unit number estimation (MUNE), which involves modelling compound muscle action …

Abstract Objective Motor Unit Number Index (MUNIX) is a quantitative neurophysiological
measure that provides an index of the number of lower motor neurons supplying a muscle. It …