Shared molecular mechanisms of membrane transporters
D Drew, O Boudker - Annual review of biochemistry, 2016 - annualreviews.org
The determination of the crystal structures of small-molecule transporters has shed light on
the conformational changes that take place during structural isomerization from outward-to …
the conformational changes that take place during structural isomerization from outward-to …
GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters
Glucose is the primary fuel to life on earth. Cellular uptake of glucose is a fundamental
process for metabolism, growth, and homeostasis. Three families of secondary glucose …
process for metabolism, growth, and homeostasis. Three families of secondary glucose …
Neurotransmitter and psychostimulant recognition by the dopamine transporter
KH Wang, A Penmatsa, E Gouaux - Nature, 2015 - nature.com
Abstract Na+/Cl–-coupled biogenic amine transporters are the primary targets of therapeutic
and abused drugs, ranging from antidepressants to the psychostimulants cocaine and …
and abused drugs, ranging from antidepressants to the psychostimulants cocaine and …
Ultra-stable organic fluorophores for single-molecule research
Fluorescence provides a mechanism for achieving contrast in biological imaging that
enables investigations of molecular structure, dynamics, and function at high spatial and …
enables investigations of molecular structure, dynamics, and function at high spatial and …
X-ray structures of LeuT in substrate-free outward-open and apo inward-open states
H Krishnamurthy, E Gouaux - Nature, 2012 - nature.com
Neurotransmitter sodium symporters are integral membrane proteins that remove chemical
transmitters from the synapse and terminate neurotransmission mediated by serotonin …
transmitters from the synapse and terminate neurotransmission mediated by serotonin …
Fluorescence resonance energy transfer at the single-molecule level
Fluorescence resonance energy transfer (FRET) is a powerful spectroscopic method for
measuring distances in the 2–8 nm range. Often, conformational changes and molecular …
measuring distances in the 2–8 nm range. Often, conformational changes and molecular …
The solute carrier 6 family of transporters
The solute carrier 6 (SLC6) family of the human genome comprises transporters for
neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family …
neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family …
De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder
De novo genetic variation is an important class of risk factors for autism spectrum disorder
(ASD). Recently, whole-exome sequencing of ASD families has identified a novel de novo …
(ASD). Recently, whole-exome sequencing of ASD families has identified a novel de novo …
Structural biology of solute carrier (SLC) membrane transport proteins
The human solute carriers (SLCs) comprise over 400 different transporters, organized into
65 families (http://slc. bioparadigms. org/) based on their sequence homology and transport …
65 families (http://slc. bioparadigms. org/) based on their sequence homology and transport …
A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters
L Malinauskaite, M Quick, L Reinhard… - Nature structural & …, 2014 - nature.com
Neurotransmitter/sodium symporters (NSSs) terminate synaptic signal transmission by Na+-
dependent reuptake of released neurotransmitters. Key conformational states have been …
dependent reuptake of released neurotransmitters. Key conformational states have been …