Metastasis formation is the major cause of death in most patients with cancer. Despite
extensive research, targeting metastatic seeding and colonization is still an unresolved …

Tumors undergo metabolic transformations to sustain uncontrolled proliferation, avoid cell
death, and seed in secondary organs. An increased focus on cancer lipid metabolism has …

Metastasis formation is a complex process, involving multiple crucial steps, which are
controlled by different regulatory mechanisms. In this context, the contribution of cancer …

Cancer remains the second leading cause of mortality worldwide. In the course of this
multistage and multifactorial disease, a set of alterations takes place, with genetic and …

Colorectal cancer (CRC) is the second leading cause of cancer mortality worldwide. The
dysbiotic gut microbiota and its metabolite secretions play a significant role in CRC …

Inhibition of de novo palmitate synthesis via fatty acid synthase (FASN) inhibition provides
an unproven approach to cancer therapy with a strong biological rationale. FASN …

Altered metabolism in cancer cells is pivotal for tumor growth, most notably by providing
energy, reducing equivalents and building blocks while several metabolites exert a …

Pyruvate occupies a central metabolic node by virtue of its position at the crossroads of
glycolysis and the tricarboxylic acid (TCA) cycle and its production and fate being governed …

Metabolic reprogramming is a central feature of transformed cells. Cancer metabolism is
now fully back in the focus of cancer research, as the interactions between oncogenic …

MicroRNAs (miRNAs) are non-coding small RNAs that function as negative regulators of
gene expression involving in the tumor biology. ATP citrate lyase (ACLY), a key enzyme …