Mitochondrial dysfunction is a central aspect of aging and neurodegenerative diseases,
including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and …

Huntington's disease (HD) is an autosomal dominantly inherited neurodegenerative
disorder caused by expanded CAG trinucleotide repeats (> 36) in exon 1 of HTT gene that …

The polyglutamine expansion of huntingtin (mHTT) causes Huntington disease (HD) and
neurodegeneration, but the mechanisms remain unclear. Here, we found that mHtt promotes …

A long-standing goal of amyloid research has been to characterize the structural basis of the
rate-determining nucleating event. However, the ephemeral nature of nucleation has made …

Huntington's disease (HD) is caused by a polyglutamine tract expansion in huntingtin (HTT).
Despite HTTs ubiquitous expression, there is early and robust vulnerability in striatum, the …

Mitochondria are essential dynamic organelles for energy production. Mitochondria
dynamically change their shapes tightly coupled to fission and fusion. Imbalance of fission …

The protein mutated in Huntington disease (HD), mutant huntingtin (mHtt), is expressed
throughout the brain and body. However, the pathology of HD is characterized by early and …

Huntington disease (HD) is a dominantly inherited disorder caused by a CAG expansion
mutation in the huntingtin (HTT) gene, which results in the HTT protein that contains an …

Transcriptional dysregulation in Huntington's disease (HD) is an early event that shapes the
brain transcriptome by both the depletion and ectopic activation of gene products that …

In patients with Huntington's disease (HD), the protein huntingtin (Htt) has an expanded
polyglutamine (poly-Q) tract. HD results in early loss of medium spiny neurons in the …